Organization of immunological memory by bone marrow stroma

被引：182

作者：

Tokoyoda, Koji ^{[1
,2
]}

Hauser, Anja E. ^{[1
]}

Nakayama, Toshinori ^{[2
]}

Radbruch, Andreas ^{[1
]}

机构：

[1] Leibniz Inst, German Rheumatism Res Ctr DRFZ, D-10117 Berlin, Germany

[2] Chiba Univ, Grad Sch Med, Dept Immunol, Chiba 2608670, Japan

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 03期

关键词：

MESENCHYMAL STEM-CELLS; FOLLICULAR DENDRITIC CELLS; LIVED PLASMA-CELLS; THERAPY POSITION STATEMENT; ACTIVATED T-CELLS; B-CELLS; LYMPH-NODE; RETICULAR CELLS; HOMEOSTATIC PROLIFERATION; ADHESION MOLECULE-1;

D O I：

10.1038/nri2727

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunological memory is a hallmark of the adaptive immune system. Plasma cells and memory B and T cells collectively provide protective immunity and effective secondary immune responses to invading pathogens. Here, we discuss how mesenchymal stromal cells regulate immunological memory by organizing defined numbers of dedicated survival niches for plasma cells and memory T cells in the bone marrow and also, to a lesser extent, in secondary lymphoid organs. An understanding of the biology of mesenchymal stromal cells and their interaction with cells of the immune system is key to fully understanding immunological memory.

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页码：193 / 200

页数：8

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