CCTG CO.26: Updated analysis and impact of plasma-detected microsatellite stability (MSS) and tumor mutation burden (TMB) in a phase II trial of durvalumab (D) plus tremelimumab (T) and best supportive care (BSC) versus BSC alone in patients (pts) with refractory metastatic colorectal carcinoma (rmCRC).

被引：15

作者：

Chen, Eric Xueyu

Jonker, Derek J.

Loree, Jonathan M.

Kennecke, Hagen F.

Berry, Scott R.

Couture, Felix

Ahmad, Chaudhary E.

Goffin, John R.

Kavan, Petr

Harb, Mohammed

Colwell, Bruce

Samimi, Setareh

Samson, Benoit

Abbas, Tahir

Aucoin, Nathalie

Aubin, Francine

Koski, Sheryl L.

Wei, Alice Chia-chi

Tu, Dongsheng

O'Callaghan, Christopher J.

机构：

[1] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada

[2] Univ Ottawa, Ottawa Hosp Res Inst, Ottawa, ON, Canada

[3] BC Canc, Vancouver, BC, Canada

[4] Virginia Mason Hosp & Med Ctr, Seattle, WA USA

[5] Univ Toronto, Odette Canc Ctr, Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada

[6] Ctr Hosp Univ Quebec, Quebec City, PQ, Canada

[7] Newfoundland Canc, St John, NF, Canada

[8] Juravinski Canc Ctr, Burlington, ON, Canada

[9] McGill Univ, Montreal, PQ, Canada

[10] Moncton Hosp, Moncton, NB, Canada

[11] Nova Scotia Canc Ctr, Halifax, NS, Canada

[12] Univ Montreal, Sacre Coeur Hosp, Montreal, PQ, Canada

[13] Hop Charles LeMoyne, Quebec City, PQ, Canada

[14] Univ Saskatchewan, Saskatoon Canc Ctr, Saskatchewan Canc Agcy, Saskatoon, SK, Canada

[15] Hop Cite Sante Laval, Laval, PQ, Canada

[16] CHUM, Montreal, PQ, Canada

[17] Cross Canc Inst, Edmonton, AB, Canada

[18] Univ Toronto, Toronto, ON, Canada

[19] Queens Univ, Canadian Canc Trials Grp, Kingston, ON, Canada

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2019年 / 37卷 / 15期

关键词：

D O I：

10.1200/JCO.2019.37.15_suppl.3512

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

3512

引用

页数：2