Carbohydrate biomarkers for future disease detection and treatment

被引：23
作者：
Cheng YunFeng [2 ]
Li MinYong [1 ]
Wang ShaoRu [2 ]
Peng HanJing [2 ]
Reid, Suazette [2 ]
Ni NanTing [2 ]
Fang Hao [1 ]
Xu WenFang [1 ]
Wang BingHe [2 ]
机构：
[1] Shandong Univ, Sch Pharm, Dept Med Chem, Jinan 250012, Peoples R China
[2] Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA
来源：
SCIENCE CHINA-CHEMISTRY | 2010年 / 53卷 / 01期
基金：
美国国家卫生研究院;
关键词：
carbohydrates; biomarkers; imaging agents; boronolectins; PROSTATE-SPECIFIC ANTIGEN; SIALYL-LEWIS-X; D-GLUCOSYL-HYDROXYMETHYLURACIL; IN-VITRO SELECTION; ACID FLUORESCENT REPORTER; PLASMA-FIBRINOGEN LEVELS; BORONIC-ACID; PROTEIN GLYCOSYLATION; CELL-ADHESION; NONENZYMATIC GLYCOSYLATION;
D O I：
10.1007/s11426-010-0021-3
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Carbohydrates are considered as one of the most important classes of biomarkers for cell types, disease states, protein functions, and developmental states. Carbohydrate "binders" that can specifically recognize a carbohydrate biomarker can be used for developing novel types of site specific delivery methods and imaging agents. In this review, we present selected examples of important carbohydrate biomarkers and how they can be targeted for the development of therapeutic and diagnostic agents. Examples are arranged based on disease categories including (1) infectious diseases, (2) cancer, (3) inflammation and immune responses, (4) signal transduction, (5) stem cell transformation, (6) embryo development, and ( 7) cardiovascular diseases, though some issues cross therapeutic boundaries.
引用
收藏
页码：3 / 20
页数：18
相关论文
共 337 条
[11]  
Babino A, 2000, INT J CANCER, V86, P753, DOI 10.1002/(SICI)1097-0215(20000615)86:6<753::AID-IJC1>3.0.CO
[12]  
2-#
[13]   Identification of novel inhibitors of the SARS coronavirus main protease 3CLpro [J].
Bacha, U ;
Barrila, J ;
Velazquez-Campoy, A ;
Leavitt, SA ;
Freire, E .
BIOCHEMISTRY, 2004, 43 (17) :4906-4912
[14]   Cyanide-sensitive fluorescent probes [J].
Badugu, R ;
Lakowicz, JR ;
Geddes, CD .
DYES AND PIGMENTS, 2005, 64 (01) :49-55
[15]   Excitation and emission wavelength ratiometric cyanide-sensitive probes for physiological sensing [J].
Badugu, R ;
Lakowicz, JR ;
Geddes, CD .
ANALYTICAL BIOCHEMISTRY, 2004, 327 (01) :82-90
[16]   A wavelength-ratiometric fluoride-sensitive probe based on the quinolinium nucleus and boronic acid moiety [J].
Badugu, R ;
Lakowicz, JR ;
Geddes, CD .
SENSORS AND ACTUATORS B-CHEMICAL, 2005, 104 (01) :103-110
[17]   Anion sensing using quinolinium based boronic acid probes [J].
Badugu, R ;
Lakowicz, JR ;
Geddes, CD .
CURRENT ANALYTICAL CHEMISTRY, 2005, 1 (02) :157-170
[18]   Targeting the glycans of gp120: a novel approach aimed at the Achilles heel of HIV [J].
Balzarini, O .
LANCET INFECTIOUS DISEASES, 2005, 5 (11) :726-731
[19]   Glycosylation of serum ribonuclease 1 indicates a major endothelial origin and reveals an increase in core fucosylation in pancreatic cancer [J].
Barrabes, Silvia ;
Pages-Pons, Lluis ;
Radcliffe, Catherine M. ;
Tabares, Gloria ;
Fort, Esther ;
Royle, Louise ;
Harvey, David J. ;
Moenner, Michel ;
Dwek, Raymond A. ;
Rudd, Pauline M. ;
De Llorens, Rafael ;
Peracaula, Rosa .
GLYCOBIOLOGY, 2007, 17 (04) :388-400
[20]   Bioorthogonal click chemistry: Covalent labeling in living systems [J].
Baskin, Jeremy M. ;
Bertozzi, Carolyn R. .
QSAR & COMBINATORIAL SCIENCE, 2007, 26 (11-12) :1211-1219
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