Carbohydrate biomarkers for future disease detection and treatment

被引：23

作者：

Cheng YunFeng ^{[2
]}

Li MinYong ^{[1
]}

Wang ShaoRu ^{[2
]}

Peng HanJing ^{[2
]}

Reid, Suazette ^{[2
]}

Ni NanTing ^{[2
]}

Fang Hao ^{[1
]}

Xu WenFang ^{[1
]}

Wang BingHe ^{[2
]}

机构：

[1] Shandong Univ, Sch Pharm, Dept Med Chem, Jinan 250012, Peoples R China

[2] Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA

来源：

SCIENCE CHINA-CHEMISTRY | 2010年 / 53卷 / 01期

基金：

美国国家卫生研究院;

关键词：

carbohydrates; biomarkers; imaging agents; boronolectins; PROSTATE-SPECIFIC ANTIGEN; SIALYL-LEWIS-X; D-GLUCOSYL-HYDROXYMETHYLURACIL; IN-VITRO SELECTION; ACID FLUORESCENT REPORTER; PLASMA-FIBRINOGEN LEVELS; BORONIC-ACID; PROTEIN GLYCOSYLATION; CELL-ADHESION; NONENZYMATIC GLYCOSYLATION;

D O I：

10.1007/s11426-010-0021-3

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Carbohydrates are considered as one of the most important classes of biomarkers for cell types, disease states, protein functions, and developmental states. Carbohydrate "binders" that can specifically recognize a carbohydrate biomarker can be used for developing novel types of site specific delivery methods and imaging agents. In this review, we present selected examples of important carbohydrate biomarkers and how they can be targeted for the development of therapeutic and diagnostic agents. Examples are arranged based on disease categories including (1) infectious diseases, (2) cancer, (3) inflammation and immune responses, (4) signal transduction, (5) stem cell transformation, (6) embryo development, and ( 7) cardiovascular diseases, though some issues cross therapeutic boundaries.

引用

页码：3 / 20

页数：18

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