Novel 1, 2, 4-Triazoles as Antifungal Agents

被引：65

作者：

Kazeminejad, Zahra ^{[1
]}

Marzi, Mahrokh ^{[2
]}

Shiroudi, Abolfazl ^{[3
]}

Kouhpayeh, Seyed Amin ^{[4
]}

Farjam, Mojtaba ^{[2
,4
]}

Zarenezhad, Elham ^{[2
]}

机构：

[1] Islamic Azad Univ, Tonekabon Branch, Young Researchers & Elite Club, Tonekabon, Iran

[2] Fasa Univ Med Sci, Noncommunicable Dis Res Ctr, Fasa, Iran

[3] Islamic Azad Univ, East Tehran Branch, Young Researchers & Elite Club, Tehran, Iran

[4] Fasa Univ Med Sci, Sch Med, Dept Med Pharmacol, Fasa, Iran

来源：

BIOMED RESEARCH INTERNATIONAL | 2022年 / 2022卷

关键词：

IN-VITRO EVALUATION; 1,2,4-TRIAZOLE DERIVATIVES; BIOLOGICAL-ACTIVITY; INVASIVE ASPERGILLOSIS; TRIAZOLE DERIVATIVES; FUNGICIDAL ACTIVITY; MOLECULAR DOCKING; EXTENDED-SPECTRUM; AMPHOTERICIN-B; DESIGN;

D O I：

10.1155/2022/4584846

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The development of innovative antifungal agents is essential. Some fungicidal agents are no longer effective due to resistance development, various side effects, and high toxicity. Therefore, the synthesis and development of some new antifungal agents are necessary. 1,2,4-Triazole is one of the most essential pharmacophore systems between five-membered heterocycles. The structure-activity relationship (SAR) of this nitrogen-containing heterocyclic compound showed potential antifungal activity. The 1,2,4-triazole core is present as the nucleus in a variety of antifungal drug categories. The most potent and broad activity of triazoles have confirmed them as pharmacologically significant moieties. The goal of this review is to highlight recent developments in the synthesis and SAR study of 1,2,4-triazole as a potential fungicidal compound. In this study, we provide the results of a biological activity evaluation using various structures and figures. Literature investigation showed that 1, 2, 4-triazole derivatives reveal the extensive span of antifungal activity. This review will assist researchers in the development of new potential antifungal drug candidates with high effectiveness and selectivity.

引用

页数：39

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