Inflammasome activation and evasion by bacterial pathogens

被引：31

作者：

Ta, Atri ^{[1
]}

Vanaja, Sivapriya Kailasan ^{[1
]}

机构：

[1] UConn Hlth Sch Med, Dept Immunol, 263 Farmington Ave, Farmington, CT 06030 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2021年 / 68卷

基金：

美国国家卫生研究院;

关键词：

INNATE IMMUNE DETECTION; NLRP3; INFLAMMASOME; PYRIN INFLAMMASOME; NLRC4; HOST-DEFENSE; GASDERMIN D; RECOGNITION; PYROPTOSIS; CASPASES; PROMOTES;

D O I：

10.1016/j.coi.2020.11.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Innate immune system plays an essential role in combating infectious diseases by recognizing invading pathogens and activating host defense response. Inflammasomes complexes are a central component of the cytosolic innate immune surveillance and are vital in host defense against bacterial pathogens. Bacterial products or pathogen-induced modifications in the intracellular environment are sensed by the inflammasome receptors that form complexes that serve as a platform for caspase-1-dependent or caspase-11-dependent induction of pyroptosis and secretion of cytokines, IL-1 beta and IL-18. However, several pathogenic bacteria have developed strategies to evade inflammasome activation. This review highlights the recent advances in the mechanism of inflammasome activation by bacterial pathogens and some of the bacterial evasion strategies of inflammasome activation.

引用

页码：125 / 133

页数：9

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