Renal cell-urinary crystal interactions

被引：40

作者：

Lieske, JC ^{[1
]}

Toback, FG ^{[1
]}

机构：

[1] Univ Chicago, Dept Med, Chicago, IL 60637 USA

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2000年 / 9卷 / 04期

关键词：

D O I：

10.1097/00041552-200007000-00005

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Crystals of calcium oxalate and calcium phosphate bind to anionic molecules on the apical surface of renal collecting duct cells. Atomic arrays on crystal faces interact stereospecifically with cell-surface anions to bind crystals that nucleate in tubular fluid, or those that nucleate directly on the plasma membrane. The internalization of adherent crystals, changes in gene expression, and secretion of specific proteins ensue, and appear to be important processes in crystal retention and kidney Stone pathogenesis. Curr Opin Nephrol Hypertens 9:349-355. (C) 2000 Lippincott Williams & Wilkins.

引用

页码：349 / 355

页数：7

共 71 条

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ANDERSON CK, 1969, RENAL STONE RES S, P133

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