Straightforward stereoselective synthesis of polyfunctionalized cyclohexenols using a multicomponent approach

被引：11

作者：

Basso, Andrea ^{[1
]}

Banfi, Luca ^{[1
]}

Guanti, Giuseppe ^{[1
]}

Riva, Renata ^{[1
]}

机构：

[1] Univ Genoa, Dipartimento Chim & Chim Ind, I-16146 Genoa, Italy

来源：

TETRAHEDRON | 2010年 / 66卷 / 13期

关键词：

Cyclohexenols; Multicomponent reactions; Norbornenyl amino acids; Ring-opening reactions; Enantioselective synthesis; Diversity oriented synthesis; AMINO ACID-DERIVATIVES; UGI REACTION; ASYMMETRIC-SYNTHESIS; OXABICYCLIC ALKENES; DRUG DISCOVERY; METATHESIS;

D O I：

10.1016/j.tet.2010.01.097

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An intramolecular Ugi 5-centre-4-component reaction (U-5C-4CR) followed by a palladium-catalysed ring-opening has been employed to transform oxabicycloheptene-based beta-amino acids into two families of regioisomeric polyfunctionalised cyclohexenols. The whole process is completely stereoselective and enantiomerically pure products are obtained in high overall yields. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2390 / 2397

页数：8

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