ISOLATION AND CHARACTERIZATION OF PHTHALATES FROM BREVIBACTERIUM MCBRELLNERI THAT CAUSE CYTOTOXICITY AND CELL CYCLE ARREST

被引：47

作者：

Rajamanikyam, Maheshwari ^{[1
]}

Vadlapudi, Varahalarao ^{[1
]}

Parvathaneni, Sai Prathima ^{[2
]}

Koude, Dhevendar ^{[1
]}

Sripadi, Prabhakar ^{[3
]}

Misra, Sunil ^{[1
]}

Amanchy, Ramars ^{[1
]}

Upadhyayula, Suryanarayana Murty ^{[1
,4
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Div Biol, Uppal Rd, Hyderabad 500007, Andhra Prades, India

[2] Indian Inst Chem Technol, CSIR, Crop Protect Chem Div, Uppal Rd, Hyderabad 500007, Andhra Prades, India

[3] Indian Inst Chem Technol, CSIR, Natl Ctr Mass Spectrometry, Uppal Rd, Hyderabad 500007, Andhra Prades, India

[4] Guwahati Med Coll & Hosp, NIPER Guwahati, Inst Pharm, 1st Floor, Gauhati 781032, India

来源：

EXCLI JOURNAL | 2017年 / 16卷

关键词：

Brevibacterium mcbrellneri; di-(2-ethylhexyl) phthalate; dibutyl phthalate; anti-bacterial; Mosquito larvicidal; cytotoxicity; cell cycle arrest; N-BUTYL PHTHALATE; DI-(2-ETHYLHEXYL) PHTHALATE; SECONDARY METABOLITES; DIPTERA-CULICIDAE; DIBUTYL PHTHALATE; MASS-SPECTROMETRY; CANCER-CELLS; SP NOV; STRAIN; BIOSYNTHESIS;

D O I：

10.17179/excli2017-145

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Bacteria belonging to the family Brevibacterieae are ubiquitous Gram positive organisms that are responsible for the feet odour and cheese aroma. Brevibacterium mcbrellneri is a relatively new member belonging to Brevibacterieae. In the current manuscript we discuss isolation of biologically active metabolites from Brevibacterium mcbrellneri. Two aromatic esters were isolated from Brevibacterium mcbrellneri by "Bioassay guided fractionation strategy" and identified as di-(2-ethylhexyl) phthalate and dibutyl phthalate by chemical characterization using biophysical techniques. The phthalate compounds show broad spectrum antibacterial activity and mosquito larvicidal activity. Mosquito larvicidal activity has been attributed to inhibition of acetylcholinesterase enzyme activity. These compounds were found to be cytotoxic in multiple cell lines causing cell cycle arrest in G1 phase.

引用

页码：375 / 387

页数：13

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