Effects of benazepril on functional activity of endothelial progenitor cells from hypertension patients

被引：11
作者：
Li, Yongdong [1 ,2 ]
Alatan, Gaole [1 ]
Ge, Zhiping [2 ]
Liu, Dan [2 ]
机构：
[1] Inner Mongolia Univ, Coll Life Sci, Hohhot 01021, Inner Mongolia, Peoples R China
[2] Inner Mongolia Med Coll, Dept Cardiol, Affiliated Hosp 3, Baotou, Inner Mongolia, Peoples R China
来源：
CLINICAL AND EXPERIMENTAL HYPERTENSION | 2014年 / 36卷 / 08期
关键词：
Adhesion; benazepril; endothelial progenitor cells; hypertension; migration; proliferation; DYSFUNCTION; REENDOTHELIALIZATION; NEOVASCULARIZATION; REGENERATION; MOBILIZATION; CONTRIBUTES; CAPACITY; MODULATE; RENIN; GAMMA;
D O I：
10.3109/10641963.2014.881840
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of angiotensin-converting enzyme inhibitors on hypertension patients regarding endothelial progenitor cell (EPC) functions is poorly understood. The aim of this study was to investigate the effects of benazepril on the proliferation, adhesion and migration capacity of EPCs and its possible mechanism. The functions of EPCs from hypertension patients were obviously reduced compared with control group, and this could be improved by benazepril in a dose-dependent manner, whereas this improvement were obviously blocked when AMD3100 were used together. Therefore, benazepril could obviously improve functions of EPCs from hypertension patients, and the potential mechanism may be related to SDF-1/CXCR4 axis.
引用
收藏
页码：545 / 549
页数：5
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