Modeling of interstitial fluid pressure in solid tumor

Interstitial fluid pressure (IFP) is one of the main obstacles for macromolecular agents uptake and distribution in solid tumors. It has been demonstrated to reduce effectiveness of different macromolecular agents used in in vivo anti-tumor therapies, which on the other hand showed very good anti-tumor properties in in vitro conditions [L.T. Baxter, R.K. Jain, Microvascular Research 37 (1989) 77-104]. With an appropriate model we demonstrated the correlation between different physiological properties of solid tumor and IFP. The model which we present showed high correlation with results from literature and thus represents a good simulation of physiological processes that govern fluid dynamics in solid tumors. One of the potential uses of presented model is drafting of future experiments which would lead to more effective chemo- or immune-therapy of solid tumors. This model could also serve as an aid to the interpretation of different experimental results concerning IFP. (C) 2000 Published by Elsevier Science B.V. All rights reserved.