Synthesis and antiangiogenic activities of 5-amino-1,3-dihydro-1,3-dioxo-2H-isoindole-2-propanoic acid derivatives

被引：5
作者：
Deng, Yong [1 ]
Yang, Da Cheng
Shen, Yi
Zhong, Yu Guo
机构：
[1] Sichuan Univ, W China Sch Pharm, Dept Med Chem, Chengdu 610041, Peoples R China
[2] Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2007年 / 18卷 / 01期
关键词：
RGD peptide sequence; integrin alpha(v)beta(3); 5-amino-1,3-dihydro-1,3-dioxo-2H-isoindole derivatives; synthesis; antiangiogenic activity;
D O I：
10.1016/j.cclet.2006.11.031
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Based on the structure-activity relationships and antiangiogenic mechanism of RGD-containing peptides, a series of 5-amino-1,3-dihydro-1,3-dioxo-2H-isoindole derivatives were synthesized. The structures were characterized by H-1 NMR, MS and elementary analysis. There ability to inhibit angiogenesis were evaluated by chick embryo chorioallantoic membrane assay at 10(-5) mol/L. Compounds 7a and 7b displayed obvious antiangiogenic activity. (c) 2006 Yong Deng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.
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收藏
页码：7 / 9
页数：3
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