Synthesis and antiangiogenic activities of 5-amino-1,3-dihydro-1,3-dioxo-2H-isoindole-2-propanoic acid derivatives

被引：5

作者：

Deng, Yong ^{[1
]}

Yang, Da Cheng

Shen, Yi

Zhong, Yu Guo

机构：

[1] Sichuan Univ, W China Sch Pharm, Dept Med Chem, Chengdu 610041, Peoples R China

[2] Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2007年 / 18卷 / 01期

关键词：

RGD peptide sequence; integrin alpha(v)beta(3); 5-amino-1,3-dihydro-1,3-dioxo-2H-isoindole derivatives; synthesis; antiangiogenic activity;

D O I：

10.1016/j.cclet.2006.11.031

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Based on the structure-activity relationships and antiangiogenic mechanism of RGD-containing peptides, a series of 5-amino-1,3-dihydro-1,3-dioxo-2H-isoindole derivatives were synthesized. The structures were characterized by H-1 NMR, MS and elementary analysis. There ability to inhibit angiogenesis were evaluated by chick embryo chorioallantoic membrane assay at 10(-5) mol/L. Compounds 7a and 7b displayed obvious antiangiogenic activity. (c) 2006 Yong Deng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.

引用

页码：7 / 9

页数：3

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