Synthesis and antiangiogenic activities of 5-amino-1,3-dihydro-1,3-dioxo-2H-isoindole-2-propanoic acid derivatives

被引：5
作者：
Deng, Yong [1 ]
Yang, Da Cheng
Shen, Yi
Zhong, Yu Guo
机构：
[1] Sichuan Univ, W China Sch Pharm, Dept Med Chem, Chengdu 610041, Peoples R China
[2] Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2007年 / 18卷 / 01期
关键词：
RGD peptide sequence; integrin alpha(v)beta(3); 5-amino-1,3-dihydro-1,3-dioxo-2H-isoindole derivatives; synthesis; antiangiogenic activity;
D O I：
10.1016/j.cclet.2006.11.031
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Based on the structure-activity relationships and antiangiogenic mechanism of RGD-containing peptides, a series of 5-amino-1,3-dihydro-1,3-dioxo-2H-isoindole derivatives were synthesized. The structures were characterized by H-1 NMR, MS and elementary analysis. There ability to inhibit angiogenesis were evaluated by chick embryo chorioallantoic membrane assay at 10(-5) mol/L. Compounds 7a and 7b displayed obvious antiangiogenic activity. (c) 2006 Yong Deng. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.
引用
收藏
页码：7 / 9
页数：3
相关论文
共 50 条
  • [21] Synthesis and crystal structure of 1,3-dihydro-4-(2-hydroxyethyl)-2H-indol-2-one
    Zhou, Ben-hua
    Cai, Jin
    Wang, Peng
    Feng, Cheng-liang
    Zong, Xi
    Ji, Min
    RESEARCH ON CHEMICAL INTERMEDIATES, 2015, 41 (04) : 2557 - 2565
  • [22] Synthesis and crystal structure of 1,3-dihydro-4-(2-hydroxyethyl)-2H-indol-2-one
    Ben-hua Zhou
    Jin Cai
    Peng Wang
    Cheng-liang Feng
    Xi Zong
    Min Ji
    Research on Chemical Intermediates, 2015, 41 : 2557 - 2565
  • [23] Synthesis, Characterization and Antifungal Activities of Amide and Acylthiourea of Substituted 2-Amino-1,3-Benzothiazole
    Wang, Junping
    Wang, Chuanping
    Wang, Hongmei
    Wei, Yan
    Lin, Jin
    Hao, Shuanghong
    NATURAL PRODUCT COMMUNICATIONS, 2025, 20 (01)
  • [24] Synthesis and BK channel-opening activity of 2-amino-1,3-thiazole derivatives
    Qi, Xiao-Lei
    Jo, Heeji
    Wang, Xue-Ying
    Ji, Tong-Tong
    Lin, Hai-Xia
    Park, Chul-Seung
    Cui, Yong-Mei
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 43
  • [25] Synthesis and evaluation of some N-Mannich bases of isoindole-1,3(2H)-dione derivatives as potential antimicrobial, anthelmintic and insecticidal agents
    Bamnela, Rita
    Shrivastava, S. P.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2014, 53 (08): : 1128 - 1135
  • [26] Synthesis and antimicrobial activity of some Mannich bases of benzimidazolyl substituted 1H-isoindole-1,3(2H) diones
    Rajpurohit, S
    Sah, P
    ASIAN JOURNAL OF CHEMISTRY, 2005, 17 (02) : 949 - 954
  • [27] Synthesis, Characterization and Antioxidant Activity of 3-(2-Amino-1,3-Selenazol-4-yl)-2H-Chromen-2-Ones Derivatives
    Alias, Nurul Zawani
    Hassan, Nurul Izzaty
    Yusoff, Zaini
    Hasan, Sharizal
    Ahmad, Wan Yaacob Wan
    SAINS MALAYSIANA, 2018, 47 (02): : 347 - 352
  • [28] Synthesis of 3-arylidene-1,3-dihydro-2H-indol-2-ones under microwave irradiation without catalyst
    Wu, MS
    Zhang, XZ
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2002, 22 (02) : 149 - 151
  • [29] Synthesis and evaluation of LOX inhibitory activity of 2-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-phenylacetamide derivatives
    Mohammadi-Farani, Ahmad
    Haqiqi, Arash
    Navid, Sahar Jamshidy
    Aliabadi, Alireza
    RESEARCH IN PHARMACEUTICAL SCIENCES, 2016, 11 (04) : 265 - 273
  • [30] Synthesis and Antibacterial Evaluation of 2-(1,3-Benzodioxol-5-ylcarbonyl)arylsulfonohydrazide Derivatives
    Siddiqa, Asia
    Aziz-ur-Rehman
    Abbasi, Muhammad Athar
    Rasool, Shahid
    Khan, Khalid Mohammed
    Ahmad, Irshad
    Afzal, Saira
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2014, 13 (10) : 1689 - 1696
12345