EUTOS score predicts survival and cytogenetic response in patients with chronic phase chronic myeloid leukemia treated with first-line imatinib

被引：16

作者：

Tao, Zhonfei ^{[1
,2
,3
,5
]}

Liu, Bingcheng ^{[1
,2
,3
]}

Zhao, Yaozhong ^{[1
,2
,3
]}

Wang, Ying ^{[1
,2
,3
]}

Zhang, Rongli ^{[1
,2
,3
]}

Han, Mingzhe ^{[1
,2
,3
]}

Zhang, Li ^{[1
,2
,3
]}

Li, Chengwen ^{[2
,3
,4
]}

Ru, Kun ^{[2
,3
,4
]}

Mi, Yingchang ^{[1
,2
,3
]}

Wang, Jianxiang ^{[1
,2
,3
,5
]}

机构：

[1] Chinese Acad Med Sci, Dept Clin Hematol, Inst Hematol, Tianjin 300020, Peoples R China

[2] Chinese Acad Med Sci, Blood Dis Hosp, Tianjin 300020, Peoples R China

[3] Peking Union Med Coll, Tianjin 300020, Peoples R China

[4] Chinese Acad Med Sci, Dept Hemopathol, Inst Hematol, Tianjin 300020, Peoples R China

[5] Chinese Acad Med Sci, State Key Lab Expt Hematol, Inst Hematol, Tianjin 300020, Peoples R China

来源：

LEUKEMIA RESEARCH | 2014年 / 38卷 / 09期

基金：

中国国家自然科学基金;

关键词：

EUTOS; Chronic myeloid leukemia; Complete cytogenetic response; Overall survival; Progression free survival; Prognosis; PATIENTS RECEIVING IMATINIB; TYROSINE KINASE INHIBITORS; EUROPEAN TREATMENT; PROGNOSTIC SCORE; FOLLOW-UP; CML; FRONTLINE; RECOMMENDATIONS; RESISTANCE; THERAPY;

D O I：

10.1016/j.leukres.2014.06.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sokal, Euro and newly developed EUTOS scoring systems were validated in 220 Chinese chronic phase chronic myeloid leukemia (CP-CML) patients treated with frontline imatinib. In the EUTOS low-risk and high-risk groups, the 5-year OS was 98.7% vs. 71.4% (P<0.0001), and the 5-year cumulative incidence of complete cytogenetic response (CCyR) was 92.4% vs. 53.8% (p<0.0001). EUTOS score also predicted progression-free survival and duration of CCyR. Low EUTOS index predicted for CCyR. However, Sokal and Euro scores mainly could not discriminate the intermediate-risk from high-risk group in either survival or CCyR. EUTOS score forecasts the prognosis of CP-CML patients treated with first-line imatinib. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1030 / 1035

页数：6

共 32 条

[1] Chronic myeloid leukemia in Asia [J].

Au, Wing Y. ;

Caguioa, Priscilla B. ;

Chuah, Charles ;

Hsu, Szu Chun ;

Jootar, Saengsuree ;

Kim, Dong-Wook ;

Kweon, Il-Young ;

O'Neil, William M. ;

Saikia, Tapan K. ;

Wang, Jianxiang .

INTERNATIONAL JOURNAL OF HEMATOLOGY, 2009, 89 (01) :14-23

[2] European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013 [J].

Baccarani, Michele ;

Deininger, Michael W. ;

Rosti, Gianantonio ;

Hochhaus, Andreas ;

Soverini, Simona ;

Apperley, Jane F. ;

Cervantes, Francisco ;

Clark, Richard E. ;

Cortes, Jorge E. ;

Guilhot, Francois ;

Hjorth-Hansen, Henrik ;

Hughes, Timothy P. ;

Kantarjian, Hagop M. ;

Kim, Dong-Wook ;

Larson, Richard A. ;

Lipton, Jeffrey H. ;

Mahon, Francois-Xavier ;

Martinelli, Giovanni ;

Mayer, Jiri ;

Mueller, Martin C. ;

Niederwieser, Dietger ;

Pane, Fabrizio ;

Radich, Jerald P. ;

Rousselot, Philippe ;

Saglio, Giuseppe ;

Saussele, Susanne ;

Schiffer, Charles ;

Silver, Richard ;

Simonsson, Bengt ;

Steegmann, Juan-Luis ;

Goldman, John M. ;

Hehlmann, Ruediger .

BLOOD, 2013, 122 (06) :872-884

[3] EUTOS score predicts early optimal response to imatinib according to the revised 2013 ELN recommendations [J].

Bonifacio, Massimiliano ;

Binotto, Gianni ;

Calistri, Elisabetta ;

Maino, Elena ;

Tiribelli, Mario .

ANNALS OF HEMATOLOGY, 2014, 93 (01) :163-164

[4] The EUTOS score identifies chronic myeloid leukeamia patients with poor prognosis treated with imatinib first or second line [J].

Breccia, Massimo ;

Finsinger, Paola ;

Loglisci, Giuseppina ;

Latagliata, Roberto ;

Mancini, Marco ;

Salaroli, Adriano ;

Serrao, Alessandra ;

Zacheo, Irene ;

Alimena, Giuliana .

LEUKEMIA RESEARCH, 2012, 36 (09) :E209-E210

[5] Imatinib for newly diagnosed patients with chronic myeloid leukemia: Incidence of sustained responses in an intention-to-treat analysis [J].

de Lavallade, Hugues ;

Apperley, Jane F. ;

Khorashad, Jamshid S. ;

Milojkovic, Dragana ;

Reid, Alistair G. ;

Bua, Marco ;

Szydlo, Richard ;

Olavarria, Eduardo ;

Kaeda, Jaspal ;

Goldman, John M. ;

Marin, David .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (20) :3358-3363

[6] Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia [J].

Druker, Brian J. ;

Guilhot, Francois ;

O'Brien, Stephen G. ;

Gathmann, Insa ;

Kantarjian, Hagop ;

Gattermann, Norbert ;

Deininger, Michael W. N. ;

Silver, Richard T. ;

Goldman, John M. ;

Stone, Richard M. ;

Cervantes, Francisco ;

Hochhaus, Andreas ;

Powell, Bayard L. ;

Gabrilove, Janice L. ;

Rousselot, Philippe ;

Reiffers, Josy ;

Cornelissen, Jan J. ;

Hughes, Timothy ;

Agis, Hermine ;

Fischer, Thomas ;

Verhoef, Gregor ;

Shepherd, John ;

Saglio, Giuseppe ;

Gratwohl, Alois ;

Nielsen, Johan L. ;

Radich, Jerald P. ;

Simonsson, Bengt ;

Taylor, Kerry ;

Baccarani, Michele ;

So, Charlene ;

Letvak, Laurie ;

Larson, Richard A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (23) :2408-2417

[7] Multidrug resistance gene (MDR1) polymorphisms are associated with major molecular responses to standard-dose imatinib in chronic myeloid leukemia [J].

Dulucq, Stephanie ;

Bouchet, Stephane ;

Turcq, Beatrice ;

Lippert, Eric ;

Etienne, Gabriel ;

Reiffers, Josy ;

Molimard, Mathieu ;

Krajinovic, Maja ;

Mahon, Francois-Xavier .

BLOOD, 2008, 112 (05) :2024-2027

[8] A proportional hazards model for the subdistribution of a competing risk [J].

Fine, JP ;

Gray, RJ .

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1999, 94 (446) :496-509

[9] A CLASS OF K-SAMPLE TESTS FOR COMPARING THE CUMULATIVE INCIDENCE OF A COMPETING RISK [J].

GRAY, RJ .

ANNALS OF STATISTICS, 1988, 16 (03) :1141-1154

[10] Frontline imatinib treatment of chronic myeloid leukemia: no impact of age on outcome, a survey by the GIMEMA CML Working Party [J].

Gugliotta, Gabriele ;

Castagnetti, Fausto ;

Palandri, Francesca ;

Breccia, Massimo ;

Intermesoli, Tamara ;

Capucci, Adele ;

Martino, Bruno ;

Pregno, Patrizia ;

Rupoli, Serena ;

Ferrero, Dario ;

Gherlinzoni, Filippo ;

Montefusco, Enrico ;

Bocchia, Monica ;

Tiribelli, Mario ;

Pierri, Ivana ;

Grifoni, Federica ;

Marzocchi, Giulia ;

Amabile, Marilina ;

Testoni, Nicoletta ;

Martinelli, Giovanni ;

Alimena, Giuliana ;

Pane, Fabrizio ;

Saglio, Giuseppe ;

Baccarani, Michele ;

Rosti, Gianantonio .

BLOOD, 2011, 117 (21) :5591-5599

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