Study on the substituents' effects of a series of synthetic chalcones against the yeast Candida albicans

被引：96
作者：
Batovska, D.
Parushev, St.
Slavova, A.
Bankova, V.
Tsvetkova, I.
Ninova, M.
Najdenski, H.
机构：
[1] Bulgarian Acad Sci, Inst Organ Chem, BU-1113 Sofia, Bulgaria
[2] Bulgarian Acad Sci, Ctr Phytochem, BU-1113 Sofia, Bulgaria
[3] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, BU-1113 Sofia, Bulgaria
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 42卷 / 01期
关键词：
chalcones; antifungal activity; Candida albicans; SAR;
D O I：
10.1016/j.ejmech.2006.08.012
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A large series of chalcones were synthesized and studied for activity against Candida albicans. The SAR analysis showed that the antifungal activity was highly dependent on the substitution pattern of the aryl rings and correlated to a large extent with the ability of compounds to interact with sulfhydryl groups. The most active were the hydroxylated chalcones as their activity related to the location of the phenolic group in the aryl ring B as follows: o-OH > p-OH similar to 3,4-di-OH > m-OH. These and other correlations obtained strongly contribute to the knowledge for design of anticandidal chalcones. (c) 2006 Elsevier Masson SAS. All rights reserved.
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页码：87 / 92
页数：6
相关论文
共 18 条
[1]  
BILGIN AA, 1987, HACETTEPE U ECZACILI, V7, P39
[2]   Antifungal activity and studies on mode of action of novel xanthoxyline-derived chalcones [J].
Boeck, P ;
Leal, PC ;
Yunes, RA ;
Cechinel, V ;
López, S ;
Sortino, M ;
Escalante, A ;
Furlán, RLE ;
Zacchino, S .
ARCHIV DER PHARMAZIE, 2005, 338 (2-3) :87-95
[3]  
Crocco Elisete I., 2004, An. Bras. Dermatol., V79, P689, DOI 10.1590/S0365-05962004000600005
[4]  
DIMMOCK JR, 1994, PHARMAZIE, V49, P909
[5]  
Dimmock JR, 1999, CURR MED CHEM, V6, P1125
[6]   Potency of Michael reaction accepters as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups [J].
Dinkova-Kostova, AT ;
Massiah, MA ;
Bozak, RE ;
Hicks, RJ ;
Talalay, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (06) :3404-3409
[7]   Antifungal chalcones from Maclura tinctoria [J].
ElSohly, HN ;
Joshi, AS ;
Nimrod, AC ;
Walker, LA ;
Clark, AM .
PLANTA MEDICA, 2001, 67 (01) :87-89
[8]  
FROCHLICH DR, 1989, COMP BIOCH PHYSL B, V94, P661
[9]   RADIOMETRIC ASSAYS FOR MAMMALIAN EPOXIDE HYDROLASES AND GLUTATHIONE S-TRANSFERASE [J].
GILL, SS ;
OTA, K ;
HAMMOCK, BD .
ANALYTICAL BIOCHEMISTRY, 1983, 131 (01) :273-282
[10]  
Hindler, 1992, CLIN MICROBIOLOGY PR
12