Study on the substituents' effects of a series of synthetic chalcones against the yeast Candida albicans

被引：96

作者：

Batovska, D.

Parushev, St.

Slavova, A.

Bankova, V.

Tsvetkova, I.

Ninova, M.

Najdenski, H.

机构：

[1] Bulgarian Acad Sci, Inst Organ Chem, BU-1113 Sofia, Bulgaria

[2] Bulgarian Acad Sci, Ctr Phytochem, BU-1113 Sofia, Bulgaria

[3] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, BU-1113 Sofia, Bulgaria

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 42卷 / 01期

关键词：

chalcones; antifungal activity; Candida albicans; SAR;

D O I：

10.1016/j.ejmech.2006.08.012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A large series of chalcones were synthesized and studied for activity against Candida albicans. The SAR analysis showed that the antifungal activity was highly dependent on the substitution pattern of the aryl rings and correlated to a large extent with the ability of compounds to interact with sulfhydryl groups. The most active were the hydroxylated chalcones as their activity related to the location of the phenolic group in the aryl ring B as follows: o-OH > p-OH similar to 3,4-di-OH > m-OH. These and other correlations obtained strongly contribute to the knowledge for design of anticandidal chalcones. (c) 2006 Elsevier Masson SAS. All rights reserved.

引用

页码：87 / 92

页数：6

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