Progress in research on childhood T-cell acute lymphocytic leukemia, Notch1 signaling pathway, and its inhibitors: A review

被引：6

作者：

Zhong Fang-Fang ^{[1
,2
]}

Yang You ^{[1
,2
]}

Liu Wen-Jun ^{[1
,2
]}

机构：

[1] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau, Peoples R China

[2] Southwest Med Univ, Affiliated Hosp, Dept Pediat, Birth Defects Clin Med Res Ctr Sichuan Prov, 25 Taiping St, Luzhou 646000, Sichuan, Peoples R China

来源：

BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES | 2021年 / 21卷 / 02期

关键词：

Childhood leukemia; Notch1 signaling pathway; T-cell acute lymphocytic leukemia; T-ALL; ACUTE LYMPHOBLASTIC-LEUKEMIA; FBXW7; MUTATIONS; AGENT DEMCIZUMAB; PTEN; RESISTANCE; DROSOPHILA; APOPTOSIS; CHILDREN; RISK; ACTIVATION;

D O I：

10.17305/bjbms.2020.4687

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Childhood leukemia is cancer that seriously threatens the life of children in China. Poor sensitivity to chemotherapy and susceptibility to drug resistance are the reasons for the treatment of T-cell acute lymphocytic leukemia (T-ALL) being extremely difficult. Moreover, traditional intensive chemotherapy regimens cause great damage to children. Therefore, it is highly important to search for targeted drugs and develop a precise individualized treatment for child patients. There are activating mutations in the NOTCH1 gene in more than sous of human T-ALLs and the Notch signaling pathway is involved in the pathogenesis of T-ALL. In this review, we summarize the progress in research on T-ALL and Notch1 signaling pathway inhibitors to provide a theoretical basis for the clinical treatment of T-ALL.

引用

页码：136 / 144

页数：9

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