Progress in research on childhood T-cell acute lymphocytic leukemia, Notch1 signaling pathway, and its inhibitors: A review

被引：6

作者：

Zhong Fang-Fang ^{[1
,2
]}

Yang You ^{[1
,2
]}

Liu Wen-Jun ^{[1
,2
]}

机构：

[1] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau, Peoples R China

[2] Southwest Med Univ, Affiliated Hosp, Dept Pediat, Birth Defects Clin Med Res Ctr Sichuan Prov, 25 Taiping St, Luzhou 646000, Sichuan, Peoples R China

来源：

BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES | 2021年 / 21卷 / 02期

关键词：

Childhood leukemia; Notch1 signaling pathway; T-cell acute lymphocytic leukemia; T-ALL; ACUTE LYMPHOBLASTIC-LEUKEMIA; FBXW7; MUTATIONS; AGENT DEMCIZUMAB; PTEN; RESISTANCE; DROSOPHILA; APOPTOSIS; CHILDREN; RISK; ACTIVATION;

D O I：

10.17305/bjbms.2020.4687

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Childhood leukemia is cancer that seriously threatens the life of children in China. Poor sensitivity to chemotherapy and susceptibility to drug resistance are the reasons for the treatment of T-cell acute lymphocytic leukemia (T-ALL) being extremely difficult. Moreover, traditional intensive chemotherapy regimens cause great damage to children. Therefore, it is highly important to search for targeted drugs and develop a precise individualized treatment for child patients. There are activating mutations in the NOTCH1 gene in more than sous of human T-ALLs and the Notch signaling pathway is involved in the pathogenesis of T-ALL. In this review, we summarize the progress in research on T-ALL and Notch1 signaling pathway inhibitors to provide a theoretical basis for the clinical treatment of T-ALL.

引用

页码：136 / 144

页数：9

共 101 条

[1] Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts [J].

Agnusdei, V. ;

Minuzzo, S. ;

Frasson, C. ;

Grassi, A. ;

Axelrod, F. ;

Satyal, S. ;

Gurney, A. ;

Hoey, T. ;

Seganfreddo, E. ;

Basso, G. ;

Valtorta, S. ;

Moresco, R. M. ;

Amadori, A. ;

Indraccolo, S. .

LEUKEMIA, 2014, 28 (02) :278-288

[2] Therapeutic modulation of Notch signalling - are we there yet? [J].

Andersson, Emma R. ;

Lendahl, Urban .

NATURE REVIEWS DRUG DISCOVERY, 2014, 13 (05) :359-380

[3] NOTCH SIGNALING [J].

ARTAVANISTSAKONAS, S ;

MATSUNO, K ;

FORTINI, ME .

SCIENCE, 1995, 268 (5208) :225-232

[4] NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study [J].

Asnafi, Vahid ;

Buzyn, Agnes ;

Le Noir, Sandrine ;

Baleydier, Frederic ;

Simon, Arnauld ;

Beldjord, Kheira ;

Reman, Oumedaly ;

Witz, Francis ;

Fagot, Thierry ;

Tavernier, Emmanuelle ;

Turlure, Pascal ;

Leguay, Thibaut ;

Huguet, Francoise ;

Vernant, Jean-Paul ;

Daniel, Francis ;

Bene, Marie-Christine ;

Ifrah, Norbert ;

Thomas, Xavier ;

Dombret, Herve ;

Macintyre, Elizabeth .

BLOOD, 2009, 113 (17) :3918-3924

[5] Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors [J].

Aste-Amezaga, Miguel ;

Zhang, Ningyan ;

Lineberger, Janet E. ;

Arnold, Beth A. ;

Toner, Timothy J. ;

Gu, Mingcheng ;

Huang, Lingyi ;

Vitelli, Salvatore ;

Vo, Kim T. ;

Haytko, Peter ;

Zhao, Jing Zhang ;

Baleydier, Frederic ;

L'Heureux, Sarah ;

Wang, Hongfang ;

Gordon, Wendy R. ;

Thoryk, Elizabeth ;

Andrawes, Marie Blanke ;

Tiyanont, Kittichoat ;

Stegmaier, Kimberly ;

Roti, Giovanni ;

Ross, Kenneth N. ;

Franlin, Laura L. ;

Wang, Hui ;

Wang, Fubao ;

Chastain, Michael ;

Bett, Andrew J. ;

Audoly, Laurent P. ;

Aster, Jon C. ;

Blacklow, Stephen C. ;

Huber, Hans E. .

PLOS ONE, 2010, 5 (02)

[6] A central role for Notch in effector CD8+ T cell differentiation [J].

Backer, Ronald A. ;

Helbig, Christina ;

Gentek, Rebecca ;

Kent, Andrew ;

Laidlaw, Brian J. ;

Dominguez, Claudia X. ;

de Souza, Yevan S. ;

van Trierum, Stella E. ;

van Beek, Ruud ;

Rimmelzwaan, Guus F. ;

ten Brinke, Anja ;

Willemsen, A. Marcel ;

van Kampen, Antoine H. C. ;

Kaech, Susan M. ;

Blander, J. Magarian ;

van Gisbergen, Klaas ;

Amsen, Derk .

NATURE IMMUNOLOGY, 2014, 15 (12) :1143-1151

[7] Notch and its oncogenic activity in human malignancies [J].

Brzozowa-Zasada, Marlena ;

Piecuch, Adam ;

Michalski, Marek ;

Segiet, Oliwia ;

Kurek, Jozef ;

Harabin-Slowinska, Marzena ;

Wojnicz, Romuald .

EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA, 2017, 49 (05) :199-209

[8] BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR [J].

Carboni, Joan M. ;

Wittman, Mark ;

Yang, Zheng ;

Lee, Francis ;

Greer, Ann ;

Hurlburt, Warren ;

Hillerman, Stephen ;

Cao, Carolyn ;

Cantor, Glenn H. ;

Dell-John, Janet ;

Chen, Cliff ;

Discenza, Lorell ;

Menard, Krista ;

Li, Aixin ;

Trainor, George ;

Vyas, Dolatrai ;

Kramer, Robert ;

Attar, Ricardo M. ;

Gottardis, Marco M. .

MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12) :3341-3349

[9] Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia [J].

Chan, Steven M. ;

Weng, Andrew P. ;

Tibshirani, Robert ;

Aster, Jon C. ;

Utz, Paul J. .

BLOOD, 2007, 110 (01) :278-286

[10] NOTCH1-induced T-cell leukemia in transgenic zebrafish [J].

Chen, J. ;

Jette, C. ;

Kanki, J. P. ;

Aster, J. C. ;

Look, A. T. ;

Griffin, J. D. .

LEUKEMIA, 2007, 21 (03) :462-471

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