Aziridine-Mediated Ligation at Phenylalanine and Tryptophan Sites

被引：3

作者：

Bajaj, Kiran ^{[1
]}

Sakhuja, Rajeev ^{[1
]}

机构：

[1] Birla Inst Technol & Sci, Dept Chem, Pilani 333031, Rajasthan, India

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2017年 / 12卷 / 15期

关键词：

amino acids; aziridines; desulfurization; ligation; peptides; NATIVE CHEMICAL LIGATION; TRACELESS STAUDINGER LIGATION; ACID-CONTAINING PEPTIDES; DESULFURIZATION CHEMISTRY; CYCLIC-PEPTIDES; PROTEINS; RECEPTORS; RESIDUES; INSIGHTS; CYSTEINE;

D O I：

10.1002/asia.201700538

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient approach towards peptide synthesis that allows easy access to variety of small peptides via one-pot aziridine-mediated ligation/desulfurization strategy has been described. The protocol afforded a library of phenylalanine- and tryptophan-containing alpha-peptides in good yields by regioselective ring-opening of aziridine-3aryl-2-carboxylates with peptide thioacids, followed by desulfurization.

引用

页码：1869 / 1874

页数：6

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