SOX5 promotes epithelial-mesenchymal transition and cell invasion via regulation of Twist1 in hepatocellular carcinoma

被引：44

作者：

Wang, Dong ^{[1
]}

Han, Sheng ^{[1
]}

Wang, Xing ^{[1
]}

Peng, Rui ^{[1
]}

Li, Xiangcheng ^{[1
]}

机构：

[1] Nanjing Med Univ, Liver Transplantat Ctr, Key Lab Living Donor Liver Transplantat, Affiliated Hosp 1,Minist Publ Hlth, Nanjing 210029, Jiangsu, Peoples R China

来源：

MEDICAL ONCOLOGY | 2015年 / 32卷 / 02期

关键词：

SOX5; HCC; EMT; Twist1; PROSTATE-CANCER; PROGRESSION; METASTASIS; EXPRESSION; DISEASE; TUMORIGENESIS; GENE;

D O I：

10.1007/s12032-014-0461-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The transcription factor sex determining region Y-box protein 5 (SOX5) plays important roles in various types of cancers. However, the expression and function of SOX5 in hepatocellular carcinoma (HCC) have not been elucidated. Here, we found that SOX5 is significantly up-regulated in HCC tissues and cell lines. Gain-and loss-of-function studies demonstrated that SOX5 promoted HCC cell migration and invasion. In addition, we revealed that SOX5 is linked to epithelial-mesenchymal transition (EMT) by regulation of Twist1. Our results indicate for the first time that SOX5 is a novel regulator of EMT in HCC and may be a potential therapeutic target for HCC metastasis.

引用

页数：8

共 34 条

[1] Transcriptional repression of TWIST1 gene by Prospero-related homeobox 1 inhibits invasiveness of hepatocellular carcinoma cells [J].

Chang, Tsung-Ming ;

Hung, Wen-Chun .

FEBS LETTERS, 2012, 586 (20) :3746-3752

[2] TWIST1 Is a Molecular Marker for a Poor Prognosis in Oral Cancer and Represents a Potential Therapeutic Target [J].

da Silva, Sabrina Daniela ;

Alaoui-Jamali, Moulay A. ;

Soares, Fernando Augusto ;

Carraro, Dirce Maria ;

Brentani, Helena Paula ;

Hier, Michael ;

Rogatto, Silvia Regina ;

Kowalski, Luiz Paulo .

CANCER, 2014, 120 (03) :352-362

[3] Hepatocellular carcinoma pathogenesis: from genes to environment [J].

Farazi, Paraskevi A. ;

DePinho, Ronald A. .

NATURE REVIEWS CANCER, 2006, 6 (09) :674-687

[4] Prognostic and diagnostic value of epithelial to mesenchymal transition markers in pulmonary neuroendocrine tumors [J].

Galvan, Jose A. ;

Astudillo, Aurora ;

Vallina, Aitana ;

Crespo, Guillermo ;

Victoria Folgueras, Maria ;

Victoria Gonzalez, Maria .

BMC CANCER, 2014, 14

[5] Cadherins and Epithelial-to-Mesenchymal Transition [J].

Gheldof, Alexander ;

Berx, Geert .

MOLECULAR BIOLOGY OF CADHERINS, 2013, 116 :317-336

[6] SOX5 Is a Candidate Gene for Chronic Obstructive Pulmonary Disease Susceptibility and Is Necessary for Lung Development [J].

Hersh, Craig P. ;

Silverman, Edwin K. ;

Gascon, Jody ;

Bhattacharya, Soumyaroop ;

Klanderman, Barbara J. ;

Litonjua, Augusto A. ;

Lefebvre, Veronique ;

Sparrow, David ;

Reilly, John J. ;

Anderson, Wayne H. ;

Lomas, David A. ;

Mariani, Thomas J. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183 (11) :1482-1489

[7] Epithelial to mesenchymal transition: Expression of the regulators snail, slug, and twist in pancreatic cancer [J].

Hotz, Birgit ;

Arndt, Marco ;

Dullat, Sonja ;

Bhargava, Sarah ;

Buhr, Heinz-J. ;

Hotz, Hubert G. .

CLINICAL CANCER RESEARCH, 2007, 13 (16) :4769-4776

[8] Transcription factor SOX-5 enhances nasopharyngeal carcinoma progression by down-regulating SPARC gene expression [J].

Huang, D-Y ;

Lin, Y-T ;

Jan, P-S ;

Hwang, Y-C ;

Liang, S-T ;

Peng, Y. ;

Huang, C-YF ;

Wu, H-C ;

Lin, C-T .

JOURNAL OF PATHOLOGY, 2008, 214 (04) :445-455

[9] SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell [J].

Jia, Xianpei ;

Li, Xuefei ;

Xu, Yingxi ;

Zhang, Shu ;

Mou, Wenjun ;

Liu, Yanhua ;

Liu, Yin ;

Lv, Dan ;

Liu, Cheng-Hu ;

Tan, Xiaoyue ;

Xiang, Rong ;

Li, Na .

JOURNAL OF MOLECULAR CELL BIOLOGY, 2011, 3 (04) :230-238

[10] The basics of epithelial-mesenchymal transition [J].

Kalluri, Raghu ;

Weinberg, Robert A. .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (06) :1420-1428

← 1 2 3 4 →