Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis

被引：732

作者：

Klose, Christoph S. N. ^{[1
]}

Artis, David ^{[1
]}

机构：

[1] Cornell Univ, Jill Roberts Inst Res Inflammatory Bowel Dis, Joan & Sanford I Weill Dept Med, Dept Microbiol & Immunol,Weill Cornell Med, New York, NY 10021 USA

来源：

NATURE IMMUNOLOGY | 2016年 / 17卷 / 07期

基金：

美国国家卫生研究院;

关键词：

NATURAL-KILLER-CELLS; GENOME-WIDE ASSOCIATION; FACTOR T-BET; ROR-GAMMA-T; HOST-DEFENSE; INTESTINAL HOMEOSTASIS; MUCOSAL IMMUNITY; TYPE-2; IMMUNITY; INDUCER CELLS; HELPER-CELLS;

D O I：

10.1038/ni.3489

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Research over the last 7 years has led to the formal identification of innate lymphoid cells (ILCs), increased the understanding of their tissue distribution and has established essential functions of ILCs in diverse physiological processes. These include resistance to pathogens, the regulation of autoimmune inflammation, tissue remodeling, cancer and metabolic homeostasis. Notably, many ILC functions appear to be regulated by mechanisms distinct from those of other innate and adaptive immune cells. In this Review, we focus on how group 2 ILC (ILC2) and group 3 ILC (ILC3) responses are regulated and how these cells interact with other immune and non-immune cells to mediate their functions. We highlight experimental evidence from mouse models and patient-based studies that have elucidated the effects of ILCs on the maintenance of tissue homeostasis and the consequences for health and disease.

引用

收藏

页码：765 / 774

页数：10

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