Antiproliferative metabolites from the endophytic fungus Penicillium sp FJ-1 isolated from a mangrove Avicennia marina

被引：25
作者：
Zheng, Chao [1 ]
Chen, Yang [1 ]
Jiang, Li-Li [2 ]
Shi, Xiao-Ming [3 ]
机构：
[1] Linyi Peoples Hosp, Dept Reparat & Reconstruct Surg, Linyi 276003, Shandong, Peoples R China
[2] Linyi Peoples Hosp, Dept Tradit Chinese Med, Linyi 276003, Shandong, Peoples R China
[3] Linyi Peoples Hosp, Dept Stomatol, Linyi 276003, Shandong, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2014年 / 10卷
关键词：
Avicennia marina; Endophytic fungus; Penicillium sp FJ-1; Anti-tumoral activities; Nude mice; BEIBU GULF MANGROVE; ALPHA-PYRONE; IN-VITRO; DERIVATIVES; DITERPENOIDS; GROWTH; FRUITS;
D O I：
10.1016/j.phytol.2014.10.011
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new compounds, named as 4-(2',3'-dihydroxy-3'-methyl-butanoxy)-phenethanol (1), and 15-hydroxy-6 alpha, 12-epoxy-7 beta, 10 alpha H, 11 beta H-spiroax-4-ene-12-one (2), were isolated from the endophytic fungus Penicillium sp. FJ-1 of Avicennia marina. Their structures were elucidated on the basis of spectroscopic analysis. Additionally, compounds 1 and 2 exhibited antiproliferative activities, and compound 2 significantly inhibited the tumor growth of human xenograft osteosarcoma in nude mice. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：272 / 275
页数：4
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