Mitochondrial dysfunction in cancer

被引：253
作者：
Modica-Napolitano, JS
Singh, KK
机构：
[1] Roswell Pk Canc Inst, Dept Canc Genet, Buffalo, NY 14263 USA
[2] Merrimack Coll, Dept Biol, N Andover, MA 01845 USA
来源：
MITOCHONDRION | 2004年 / 4卷 / 5-6期
基金：
美国国家卫生研究院;
关键词：
mitochondria; cancer; mtDNA; mitochondrial dysfunction;
D O I：
10.1016/j.mito.2004.07.027
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Nearly a century of scientific research has revealed a number of notable differences in the structure and function of mitochondria between normal and cancer cells, including differences in metabolic activity, molecular composition, and mtDNA sequence. This article reviews several of these differences and discusses their clinical implications, especially with regard to the use of mitochondria as biomarkers for early detection of cancer, or as unique cellular targets for novel and selective anti-cancer agents. (C) 2004 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
引用
收藏
页码：755 / 762
页数：8
相关论文
共 100 条
  • [1] CYTOTOXIC EFFECT OF THIACARBOCYANINE DYES ON HUMAN COLON-CARCINOMA CELLS AND INHIBITION OF BOVINE HEART MITOCHONDRIAL NADH-UBIQUINONE REDUCTASE-ACTIVITY VIA A ROTENONE-TYPE MECHANISM BY 2 OF THE DYES
    ANDERSON, WM
    DELINCK, DL
    BENNINGER, L
    WOOD, JM
    SMILEY, ST
    CHEN, LB
    [J]. BIOCHEMICAL PHARMACOLOGY, 1993, 45 (03) : 691 - 696
  • [2] Bernardi P, 1998, BIOFACTORS, V8, P273, DOI 10.1002/biof.5520080315
  • [3] The peripheral benzodiazepine receptors: a review
    Beurdeley-Thomas, A
    Miccoli, L
    Oudard, S
    Dutrillaux, B
    Poupon, MF
    [J]. JOURNAL OF NEURO-ONCOLOGY, 2000, 46 (01) : 45 - 56
  • [4] INHIBITION OF RAT COLON-TUMOR ISOGRAFT GROWTH WITH DEQUALINIUM CHLORIDE
    BLEDAY, R
    WEISS, MJ
    SALEM, RR
    WILSON, RE
    CHEN, LB
    STEELE, G
    [J]. ARCHIVES OF SURGERY, 1986, 121 (11) : 1272 - 1275
  • [5] Amplification of mitochondrial DNA in acute myeloid leukaemia
    Boultwood, J
    Fidler, C
    Mills, KI
    Frodsham, PM
    Kusec, R
    Gaiger, A
    Gale, RE
    Linch, DC
    Littlewood, TJ
    Moss, PAH
    Wainscoat, JS
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 1996, 95 (02) : 426 - 431
  • [6] BAX frameshift mutations in cell lines derived from human haemopoietic malignancies are associated with resistance to apoptosis and microsatellite instability
    Brimmell, M
    Mendiola, R
    Mangion, J
    Packham, G
    [J]. ONCOGENE, 1998, 16 (14) : 1803 - 1812
  • [7] BURGART LJ, 1995, AM J PATHOL, V147, P1105
  • [8] Oxidative phosphorylation enzymes in normal and neoplastic cell growth
    Capuano, F
    Guerrieri, F
    Papa, S
    [J]. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1997, 29 (04) : 379 - 384
  • [9] Capuano F, 1996, BIOCHEM MOL BIOL INT, V38, P1013
  • [10] ADENINE-NUCLEOTIDE TRANSPORT IN HEPATOMA MITOCHONDRIA - CHARACTERIZATION OF FACTORS INFLUENCING THE KINETICS OF ADP AND ATP UPTAKE
    CHAN, SHP
    BARBOUR, RL
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 723 (01) : 104 - 113
12345678910