Antigen-specific therapy for autoimmune disease

被引：82

作者：

Harrison, LC ^{[1
]}

Hafler, DA

机构：

[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Autoimmun & Transplantat Div, Parkville, Vic 3050, Australia

[2] Brigham & Womens Hosp, Ctr Neurol Dis, Lab Mol Immunol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 06期

关键词：

D O I：

10.1016/S0952-7915(00)00166-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The application of self-antigens as therapeutic tools is validated in inbred animal models of autoimmune disease. Mechanisms of antigen-induced tolerance (apoptosis, anergy, regulatory T cells and immune deviation) are being clarified in relation to the properties-of antigens and the modes and routes of their delivery. Mucosa-mediated tolerance remains the predominant mode of antigen-specific therapy but awaits demonstration of clinical efficacy in human autoimmune disease.

引用

页码：704 / 711

页数：8

共 68 条

[1] AN AUTOIMMUNE-DISEASE WITH MULTIPLE MOLECULAR TARGETS ABROGATED BY THE TRANSGENIC EXPRESSION OF A SINGLE AUTOANTIGEN IN THE THYMUS [J].

ALDERUCCIO, F ;

TOH, BH ;

TAN, SS ;

GLEESON, PA ;

VANDRIEL, IR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) :419-426

[2]

Anderton SM, 1998, J IMMUNOL, V161, P3357

[3] MULTIPLE LEVELS OF PERIPHERAL TOLERANCE [J].

ARNOLD, B ;

SCHONRICH, G ;

HAMMERLING, GJ .

IMMUNOLOGY TODAY, 1993, 14 (01) :12-14

[4]

Ausubel LJ, 1997, J IMMUNOL, V159, P2502

[5] Cross-reactivity of T-cell clones specific for altered peptide ligands of myelin basic protein [J].

Ausubel, LJ ;

Bieganowska, KD ;

Hafler, DA .

CELLULAR IMMUNOLOGY, 1999, 193 (01) :99-107

[6]

Barone KS, 1998, J IMMUNOL, V161, P154

[7] Potential risk of oral insulin with adjuvant for the prevention of Type I diabetes: a protocol effective in NOD mice may exacerbate disease in BB rats [J].

Bellmann, K ;

Kolb, H ;

Rastegar, S ;

Jee, P ;

Scott, FW .

DIABETOLOGIA, 1998, 41 (07) :844-847

[8]

Benson JM, 1999, J IMMUNOL, V162, P6247

[9] Systemic administration of agonist peptide blocks the progression of spontaneous CD8-mediated autoimmune diabetes in transgenic mice without bystander damage [J].

Bercovici, N ;

Heurtier, A ;

Vizler, C ;

Pardigon, N ;

Cambouris, C ;

Desreumaux, P ;

Liblau, R .

JOURNAL OF IMMUNOLOGY, 2000, 165 (01) :202-210

[10] ORAL-ADMINISTRATION OF HUMAN INSULIN TO NOD MICE GENERATES CD4(+) T-CELLS THAT SUPPRESS ADOPTIVE TRANSFER OF DIABETES [J].

BERGEROT, I ;

FABIEN, N ;

MAGUER, V ;

THIVOLET, C .

JOURNAL OF AUTOIMMUNITY, 1994, 7 (05) :655-663

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