Antigen-specific therapy for autoimmune disease

被引：81
作者：
Harrison, LC [1 ]
Hafler, DA
机构：
[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Autoimmun & Transplantat Div, Parkville, Vic 3050, Australia
[2] Brigham & Womens Hosp, Ctr Neurol Dis, Lab Mol Immunol, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Boston, MA 02115 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 06期
关键词：
D O I：
10.1016/S0952-7915(00)00166-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The application of self-antigens as therapeutic tools is validated in inbred animal models of autoimmune disease. Mechanisms of antigen-induced tolerance (apoptosis, anergy, regulatory T cells and immune deviation) are being clarified in relation to the properties-of antigens and the modes and routes of their delivery. Mucosa-mediated tolerance remains the predominant mode of antigen-specific therapy but awaits demonstration of clinical efficacy in human autoimmune disease.
引用
收藏
页码：704 / 711
页数：8
相关论文
共 68 条
  • [1] AN AUTOIMMUNE-DISEASE WITH MULTIPLE MOLECULAR TARGETS ABROGATED BY THE TRANSGENIC EXPRESSION OF A SINGLE AUTOANTIGEN IN THE THYMUS
    ALDERUCCIO, F
    TOH, BH
    TAN, SS
    GLEESON, PA
    VANDRIEL, IR
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) : 419 - 426
  • [2] Anderton SM, 1998, J IMMUNOL, V161, P3357
  • [3] MULTIPLE LEVELS OF PERIPHERAL TOLERANCE
    ARNOLD, B
    SCHONRICH, G
    HAMMERLING, GJ
    [J]. IMMUNOLOGY TODAY, 1993, 14 (01): : 12 - 14
  • [4] Ausubel LJ, 1997, J IMMUNOL, V159, P2502
  • [5] Cross-reactivity of T-cell clones specific for altered peptide ligands of myelin basic protein
    Ausubel, LJ
    Bieganowska, KD
    Hafler, DA
    [J]. CELLULAR IMMUNOLOGY, 1999, 193 (01) : 99 - 107
  • [6] Barone KS, 1998, J IMMUNOL, V161, P154
  • [7] Potential risk of oral insulin with adjuvant for the prevention of Type I diabetes: a protocol effective in NOD mice may exacerbate disease in BB rats
    Bellmann, K
    Kolb, H
    Rastegar, S
    Jee, P
    Scott, FW
    [J]. DIABETOLOGIA, 1998, 41 (07) : 844 - 847
  • [8] Benson JM, 1999, J IMMUNOL, V162, P6247
  • [9] Systemic administration of agonist peptide blocks the progression of spontaneous CD8-mediated autoimmune diabetes in transgenic mice without bystander damage
    Bercovici, N
    Heurtier, A
    Vizler, C
    Pardigon, N
    Cambouris, C
    Desreumaux, P
    Liblau, R
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 165 (01) : 202 - 210
  • [10] ORAL-ADMINISTRATION OF HUMAN INSULIN TO NOD MICE GENERATES CD4(+) T-CELLS THAT SUPPRESS ADOPTIVE TRANSFER OF DIABETES
    BERGEROT, I
    FABIEN, N
    MAGUER, V
    THIVOLET, C
    [J]. JOURNAL OF AUTOIMMUNITY, 1994, 7 (05) : 655 - 663
1234567