How to define treatment-resistant depression?

被引：15

作者：

Holtzmann, Jerome ^{[1
]}

Richieri, Raphaelle ^{[2
]}

Saba, Ghassen ^{[3
]}

Allaili, Najib ^{[4
]}

Bation, Remy ^{[5
]}

Moliere, Fanny ^{[6
]}

Nieto, Isabel ^{[4
]}

Bellivier, Frank ^{[4
]}

Bennabi, Djamila ^{[7
]}

Bubrovszky, Maxime ^{[8
]}

Camus, Vincent ^{[9
]}

Charpeaud, Thomas ^{[10
]}

Courvoisier, Pierre ^{[1
]}

Haesebaert, Frederic ^{[5
]}

Doumy, Olivier ^{[11
]}

Courtet, Philippe ^{[6
]}

El-Hage, Wissam ^{[9
]}

Garnier, Marion ^{[3
,10
]}

d'Amato, Thierry ^{[5
]}

Lancon, Christophe ^{[2
]}

Leboyer, Marion

Llorca, Pierre-Michel ^{[10
]}

Vaiva, Guillaume ^{[8
]}

Bougerol, Thierry ^{[1
]}

Aouizerate, Bruno ^{[11
]}

Haffen, Emmanuel ^{[7
]}

机构：

[1] CHU Grenoble, Hop Nord, Ctr Expert Depress Resistante Fondamental, Serv Psychiat Adulte, CS 10217, F-38043 Grenoble 9, France

[2] CHU La Concept, Pole Psychiat Ctr, Ctr Expert Depress Resistante Fondamental, F-13005 Marseille, France

[3] Hop Chenevier, Pole Psychiat Hop Univ, Ctr Expert Depress Resistante Fondamental, F-94000 Creteil, France

[4] Hop Fernand Widal, Ctr Expert Depress Resistante Fondamental, Serv Psychiat Adulte, F-75010 Paris, France

[5] Ctr Hosp Le Vinatier, Serv Univ Psychiat Adulte, Ctr Expert Depress Resistante Fondamental, BP 300 39, F-69678 Bron, France

[6] CHRU Lapeyronie, Ctr Expert Depress Resistante Fondamental, Dept Urgences & Posturgences Psychiat, F-34295 Montpellier 5, France

[7] CHU Besancon, Ctr Expert Depress Resistante Fondamental, Serv Psychiat Adulte, F-25030 Besancon, France

[8] CHRU Lille, Ctr Expert Depress Resistante Fondamental, Serv Psychiat Adulte, Hop Fontan 1, F-59037 Lille, France

[9] CHU Tours, Clin Psychiat Univ, Ctr Expert Depress Resistante Fondamental, F-37044 Tours 9, France

[10] CHU Clermont Ferrand, Ctr Expert Depress Resistante Fondamental, Serv Psychiat Adulte B, F-63003 Clermont Ferrand, France

[11] CH Charles Perrens, Ctr Expert Depress Resistante Fondamental, Pole Psychiat Gen & Univ, F-33076 Bordeaux, France

来源：

PRESSE MEDICALE | 2016年 / 45卷 / 03期

关键词：

ANTIDEPRESSANT NONRESPONDERS; DISORDER; STRATEGIES; REMISSION; AUGMENTATION; DEFINITION; SYMPTOMS;

D O I：

10.1016/j.lpm.2016.02.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The most largely used definition of the treatment-resistant depression relies on the failure of two successive trials of antidepressant treatment at an adequate dose and duration. The absence of response to previous antidepressant treatments should be assessed using specific and appropriate clinical instruments enabling a correct staging of the therapeutic resistance. A wide range of socio-demographic and clinical factors (i.e. psychiatric/somatic comorbidities) are classically associated with the therapeutic resistance. The aim of the treatment of major depression is to achieve a complete clinical remission. The presence of residual symptoms increases the risk for the subsequent occurrence of relapses and recurrences, hence facilitating the development of therapeutic resistance. The treatment-resistant depression has a deleterious impact on the social, familial or professional functioning, thereby leading to an impaired quality of life with serious socioeconomic consequences and costs.

引用

页码：323 / 328

页数：6

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