Diastereoselective zinc-mediated Barbier-type allylation and propargylation of 3-formylcephalosporins

被引：8

作者：

Keltjens, R

Vadivel, SK

de Gelder, R

Klunder, AJH

Zwanenburg, B

机构：

[1] Univ Nijmegen, NSR Inst Mol Struct Design & Synth, Dept Organ Chem, NL-6525 ED Nijmegen, Netherlands

[2] Univ Nijmegen, NSR Inst Mol Struct Design & Synth, Dept Inorgan Chem, NL-6525 ED Nijmegen, Netherlands

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 2003卷 / 09期

关键词：

aldehydes; allylations; diastereoselectivity; lactams; antibiotics; zinc;

D O I：

10.1002/ejoc.200200503

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe the allylation and propargylation of 3-formylce-phalosporins under zinc-mediated, aqueous Barbier conditions, from which the corresponding homoallylic alcohols are produced in good yields and with good-to-excellent diastereoselectivity. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).

引用

页码：1749 / 1758

页数：10