Diastereoselective zinc-mediated Barbier-type allylation and propargylation of 3-formylcephalosporins

被引：8
作者：
Keltjens, R
Vadivel, SK
de Gelder, R
Klunder, AJH
Zwanenburg, B
机构：
[1] Univ Nijmegen, NSR Inst Mol Struct Design & Synth, Dept Organ Chem, NL-6525 ED Nijmegen, Netherlands
[2] Univ Nijmegen, NSR Inst Mol Struct Design & Synth, Dept Inorgan Chem, NL-6525 ED Nijmegen, Netherlands
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 2003卷 / 09期
关键词：
aldehydes; allylations; diastereoselectivity; lactams; antibiotics; zinc;
D O I：
10.1002/ejoc.200200503
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We describe the allylation and propargylation of 3-formylce-phalosporins under zinc-mediated, aqueous Barbier conditions, from which the corresponding homoallylic alcohols are produced in good yields and with good-to-excellent diastereoselectivity. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
引用
收藏
页码：1749 / 1758
页数：10
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