Epigenetic Modifications in Cardiovascular Aging and Diseases

被引：208
作者：
Zhang, Weiqi [1 ,2 ,5 ,6 ]
Song, Moshi [4 ,5 ,6 ]
Qu, Jing [3 ,5 ,6 ]
Liu, Guang-Hui [1 ,2 ,5 ,6 ]
机构：
[1] Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Disorders, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China
[2] Chinese Acad Sci, Natl Lab Biomacromol, CAS Ctr Excellence Biomacromol, Inst Biophys, Beijing, Peoples R China
[3] Chinese Acad Sci, State Key Lab Stem Cell & Reprod Biol, Inst Zool, Beijing, Peoples R China
[4] Chinese Acad Sci, State Key Lab Membrane Biol, Inst Zool, Beijing, Peoples R China
[5] Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing, Peoples R China
[6] Univ Chinese Acad Sci, Beijing, Peoples R China
来源：
CIRCULATION RESEARCH | 2018年 / 123卷 / 07期
基金：
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词：
aging; disease; epigenomics; genomics; histones; LONG NONCODING RNA; SMOOTH-MUSCLE-CELLS; CIRCULAR RNAS; DNA METHYLATION; GENE-EXPRESSION; CARDIAC-HYPERTROPHY; MITOCHONDRIAL SIRTUINS; PTEN EXPRESSION; HEART-FAILURE; 3D GENOME;
D O I：
10.1161/CIRCRESAHA.118.312497
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aging is associated with a progressive decline in cardiovascular structure and function. Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a complex interplay of DNA methylation, histone posttranslational modifications, and dynamic nucleosome occupancy governed by numerous epigenetic factors. Advances in genomics technology have led to a profound understanding of chromatin reorganization in both cardiovascular aging and diseases. This review summarizes recent discoveries in epigenetic mechanisms involved in cardiovascular aging and diseases and discusses potential therapeutic strategies to retard cardiovascular aging and conquer related diseases through the rejuvenation of epigenetic signatures to a young state.
引用
收藏
页码：773 / 786
页数：14
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