Genetics and Causality of Triglyceride-Rich Lipoproteins in Atherosclerotic Cardiovascular Disease

被引：203
|
作者：
Rosenson, Robert S. [1 ]
Davidson, Michael H. [2 ]
Hirsh, Benjamin J. [3 ]
Kathiresan, Sekar [4 ]
Gaudet, Daniel [5 ,6 ]
机构：
[1] Icahn Sch Med Mt Sinai, New York, NY 10029 USA
[2] Univ Chicago, Pritzker Sch Med, Div Cardiol, Chicago, IL 60637 USA
[3] Mt Sinai Hosp, New York, NY 10029 USA
[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA
[5] Univ Montreal, Dept Med, ECOGENE 21, Chicoutimi, PQ, Canada
[6] Univ Montreal, Dept Med, Lipid Clin, Chicoutimi, PQ, Canada
来源：
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2014年 / 64卷 / 23期
关键词：
atherosclerosis; cardiovascular disease; genetics; triglyceride; triglyceride-rich lipoproteins; LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; APOLIPOPROTEIN C-III; ALIPOGENE TIPARVOVEC AAV1-LPLS447X; TISSUE-SPECIFIC EXPRESSION; CYTOSOLIC LIPID DROPLETS; GENOME-WIDE ASSOCIATION; EXTENDED-RELEASE NIACIN; NONFASTING TRIGLYCERIDES; SEVERE HYPERTRIGLYCERIDEMIA;
D O I：
10.1016/j.jacc.2014.09.042
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Triglycerides represent 1 component of a heterogeneous pool of triglyceride-rich lipoproteins (TGRLs). The reliance on triglycerides or TGRLs as cardiovascular disease (CVD) risk biomarkers prompted investigations into therapies that lower plasma triglycerides as a means to reduce CVD events. Genetic studies identified TGRL components and pathways involved in their synthesis and metabolism. We advocate that only a subset of genetic mechanisms regulating TGRLs contribute to the risk of CVD events. This " omic" approach recently resulted in new targets for reducing CVD events. (C) 2014 by the American College of Cardiology Foundation.
引用
收藏
页码：2525 / 2540
页数：16
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