Blood pressure-lowering interventions to prevent dementia: a systematic review and meta-analysis

被引：35
|
作者：
van Middelaar, Tessa [1 ,2 ]
van Vught, Lonneke A. [3 ]
van Gool, Willem A. [1 ]
Simons, Esther M. F. [2 ]
van den Born, Bert-Jan H. [4 ]
van Charante, Eric P. Moll [3 ]
Richard, Edo [1 ,2 ]
机构：
[1] Acad Med Ctr, Dept Neurol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Neurol, Nijmegen, Netherlands
[3] Amsterdam Publ Hlth Res Inst, Dept Gen Practice, Amsterdam, Netherlands
[4] Acad Med Ctr, Dept Internal Med, Amsterdam, Netherlands
来源：
JOURNAL OF HYPERTENSION | 2018年 / 36卷 / 09期
基金：
瑞典研究理事会; 芬兰科学院;
关键词：
antihypertensive agents; dementia; healthy lifestyle; hypertension; preventive medicine; DOUBLE-BLIND; RISK; TRIALS; PERINDOPRIL; POPULATION; INDAPAMIDE; DISEASE;
D O I：
10.1097/HJH.0000000000001829
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Our objective was to study the preventive effect of lowering blood pressure (BP) by medication and/or lifestyle changes on incident all-cause dementia, Alzheimer's disease and vascular dementia. In this systematic review, we included randomized controlled trials with a BP-lowering intervention. Of the nine included trials, seven assessed the effect of antihypertensive medication and two of a lifestyle or combined intervention. In the intervention arm, 1041 out of 29029 (3.6%) participants were diagnosed with dementia compared with 1090 out of 28653 (3.8%) controls during a median follow-up of 3.9 years [range 2-10], resulting in a pooled risk ratio of 0.93 (95% confidence interval 0.84-1.02; I-2 16%). Three trials specified dementia subtypes, with no significant effect on Alzheimer's disease or vascular dementia. To conclude, lowering BP by medication and/or lifestyle changes did not lead to a significantly reduced risk of dementia. This appeared independent of dementia subtype.
引用
收藏
页码：1780 / 1787
页数：8
相关论文
共 50 条
  • [31] Blood Pressure-Lowering Treatment After Subacute Stroke to Prevent Recurrent Stroke, Major Vascular Events, and Dementia
    Zonneveld, Thomas P.
    Richard, Edo
    Vergouwen, Mervyn D. I.
    Nederkoorn, Paul J.
    de Haan, Rob J.
    Roos, Yvo B. W. E. M.
    Kruyt, Nyika D.
    STROKE, 2018, 49 (11) : E309 - E310
  • [32] Placebo-Controlled Trials of Blood Pressure-Lowering Therapies for Primary Prevention of Dementia
    Staessen, Jan A.
    Thijs, Lutgarde
    Richart, Tom
    Odili, Augustine N.
    Birkenhager, Willem H.
    HYPERTENSION, 2011, 57 (02) : E6 - E7
  • [33] Association between ambulatory blood pressure monitoring patterns with cognitive function and risk of dementia: a systematic review and meta-analysis
    Gavriilaki, Maria
    Anyfanti, Panagiota
    Mastrogiannis, Konstantinos
    Gavriilaki, Eleni
    Lazaridis, Antonios
    Kimiskidis, Vasilios
    Gkaliagkousi, Eugenia
    AGING CLINICAL AND EXPERIMENTAL RESEARCH, 2023, 35 (4) : 745 - 761
  • [34] Effects of artichoke on blood pressure: A systematic review and meta-analysis
    Moradi, Mozhgan
    Sohrabi, Ghazale
    Golbidi, Mojgan
    Yarmohammadi, Samira
    Hemati, Niloofar
    Campbell, Marilyn S.
    Moradi, Sajjad
    Kermani, Mohammad Ali Hojjati
    Farzaei, Mohammad Hosein
    COMPLEMENTARY THERAPIES IN MEDICINE, 2021, 57
  • [35] Achieved systolic blood pressure in older people: a systematic review and meta-analysis
    Moraes, Aline A. I.
    Baena, Cristina P.
    Muka, Taulant
    Bano, Arjola
    Buitrago-Lopez, Adriana
    Zazula, Ana
    Erbano, Bruna O.
    Schio, Nicolle A.
    Guedes, Murilo H.
    Bramer, Wichor M.
    Franco, Oscar H.
    Faria-Neto, Jose Rocha
    BMC GERIATRICS, 2017, 17
  • [36] Effects of genistein on blood pressure: A systematic review and meta-analysis
    Hemati, Niloofar
    Asis, Marzieh
    Moradi, Sajjad
    Mollica, Adriano
    Stefanucci, Azzurra
    Nikfar, Shekoufeh
    Mohammadi, Elham
    Farzaei, Mohammad Hosein
    Abdollahi, Mohammad
    FOOD RESEARCH INTERNATIONAL, 2020, 128
  • [37] Benzodiazepines Reduce Blood Pressure in Short Term: A Systematic Review and Meta-analysis
    Solanki, Bhupinder
    Goel, Ridhi
    Gupta, Lalit K.
    CURRENT HYPERTENSION REPORTS, 2023, 25 (10) : 335 - 341
  • [38] The effects of blood pressure reduction and of different blood pressure-lowering regimens on major cardiovascular events according to baseline blood pressure: meta-analysis of randomized trials
    Czernichow, Sebastien
    Zanchetti, Alberto
    Turnbull, Fiona
    Barzi, Federica
    Ninomiya, Toshiaru
    Kengne, Andre-Pascal
    Lambers Heerspink, Hiddo J.
    Perkovic, Vlado
    Huxley, Rachel
    Arima, Hisatomi
    Patel, Anushka
    Chalmers, John
    Woodward, Mark
    MacMahon, Stephen
    Neal, Bruce
    JOURNAL OF HYPERTENSION, 2011, 29 (01) : 4 - 16
  • [39] Blood Pressure and Risks of Cognitive Impairment and Dementia A Systematic Review and Meta-Analysis of 209 Prospective Studies
    Ou, Ya-Nan
    Tan, Chen-Chen
    Shen, Xue-Ning
    Xu, Wei
    Hou, Xiao-He
    Dong, Qiang
    Tan, Lan
    Yu, Jin-Tai
    HYPERTENSION, 2020, 76 (01) : 217 - 225
  • [40] Brisk Walking Exercise Has Benefits of Lowering Blood Pressure in Hypertension Sufferers: A Systematic Review and Meta-Analysis
    Malem, Rehmaita
    Ristiani, Ristiani
    Puteh, Muhibbullah Ali
    IRANIAN JOURNAL OF PUBLIC HEALTH, 2024, 53 (04) : 774 - 784
12345