Insulin-Like Growth Factor Axis in Pregnancy and Gestational Diabetes Mellitus

被引：13

作者：

Anderlova, K. ^{[1
,2
,5
]}

Cinkajzlova, A. ^{[2
,3
,4
]}

Simjak, P. ^{[1
,2
]}

Klouckova, J. ^{[2
,3
,4
]}

Kratochvilova, H. ^{[2
,3
,4
]}

Lacinova, Z. ^{[2
,4
,5
]}

Kavalkova, P. ^{[2
,3
]}

Krejci, H. ^{[1
,2
,5
]}

Mraz, M. ^{[2
,3
,6
]}

Parizek, A. ^{[1
,2
]}

Haluzik, M. ^{[2
,3
,4
,6
,7
]}

Krsek, M. ^{[2
,5
,8
,9
]}

机构：

[1] Charles Univ Prague, Fac Med 1, Gynaecol & Obstet Dept, Prague, Czech Republic

[2] Gen Univ Hosp, Prague, Czech Republic

[3] Charles Univ Prague, Fac Med 1, Inst Med Biochem & Lab Diagnost, Prague, Czech Republic

[4] Inst Clin & Expt Med, Ctr Expt Med, Prague, Czech Republic

[5] Charles Univ Prague, Fac Med 1, Dept Med 3, Prague, Czech Republic

[6] Diabet Ctr, Inst Clin & Expt Med, Dept Diabet, Prague, Czech Republic

[7] Inst Endocrinol, Dept Obesitol, Prague, Czech Republic

[8] Charles Univ Prague, Fac Med 3, Dept Internal Med 2, Prague, Czech Republic

[9] Univ Hosp Kralovske Vinohrady, Prague, Czech Republic

来源：

PHYSIOLOGICAL RESEARCH | 2019年 / 68卷 / 05期

关键词：

Insulin-like growth factor; IGF-binding proteins; Gestational diabetes mellitus; Insulin sensitivity; Adipose tissue; FACTOR BINDING-PROTEINS; FACTOR-I; EXPRESSION; HORMONE; IGFBP-1; PEPTIDE; GENES;

D O I：

10.33549/physiolres.934093

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The insulin-like growth factor (IGF) is involved in the regulation of growth and metabolism. The aim of this study was to determine selected parameters of IGF system at systemic and local levels [subcutaneous (SAT) and visceral adipose tissue (VAT)] to assess its possible role in gestational diabetes mellitus (GDM). 37 pregnant women (21 with GDM and 16 without GDM) and 15 age-matched non-pregnant females were included in the study. Blood samples were taken in 28-32 and 36-38 weeks of gestation and 6-12 months after delivery. SAT and VAT samples were obtained during delivery or surgery. Compared with nonpregnant women, serum IGF-1 and IGFBP-3 were increased in both groups of pregnant women. IGF-2 was elevated only in GDM women from 36 weeks of gestation culminating 6 months after delivery (p=0.003). Serum IGFBP-3 was increased and IGFBP-4 decreased in GDM women vs. pregnant women without GDM during the whole study (IGFBP-3: p<0.001 for GDM vs. non-GDM; IGFBP-4: p=0.004 for GDM vs. non-GDM). Pregnant women with GDM had decreased mRNA expression of IGF-1, IGF-1R and IGF-2R and IGFBP-4 in VAT and IGF-1R in SAT compared to pregnant women without GDM. Changes in local activity of IGF are associated with the development of GDM.

引用

页码：807 / 816

页数：10

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