A mitochondria-targetable fluorescent probe for detection of bisulfite in living cells

被引：8

作者：

Guo, Xiao ^{[1
]}

Zhu, Wei-Jin ^{[1
]}

Wei, Xue-Rui ^{[2
]}

Xu, Yu-Jie ^{[2
]}

Sun, Ru ^{[1
]}

Ge, Jian-Feng ^{[1
,3
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, 199 RenAi Rd, Suzhou 215123, Peoples R China

[2] Soochow Univ, Jiangsu Higher Educ Inst, Collaborat Innovat Ctr Radiat Med, State Key Lab Radiat Med & Protect,Sch Radiat Med, Suzhou 215123, Peoples R China

[3] Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Jiangsu Key Lab Med Opt, Suzhou 215163, Peoples R China

来源：

ANALYTICAL METHODS | 2018年 / 10卷 / 31期

基金：

中国国家自然科学基金;

关键词：

SO2; DERIVATIVES; SELECTIVE DETECTION; RATIOMETRIC DETECTION; SULFUR-DIOXIDE; SULFITE; PLATFORM; SENSORS; SAMPLES; ANIONS; ESIPT;

D O I：

10.1039/c8ay01543k

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new colorimetric semi-cyanine fluorescent probe (3) based on benzo[g]indolium was designed and prepared. Probe 3 exhibited a clear OFF-ON fluorescence response at 460 nm toward HSO3- (0-8.0 eq.) within a short response time (3 min). In addition, probe 3 had good selectivity and competitiveness, with excellent sensitivity and a low detection limit (4.4 nM). The detection mechanism relied on nucleophilic HSO3- attacking the C?C double bond in a 1,4-nucleophilic addition reaction. Importantly, the confocal fluorescence results indicated that probe 3 targeted mitochondria and could detect HSO3- in living cells.

引用

页码：3872 / 3877

页数：6

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