Neutrophils in Psoriasis

被引：214

作者：

Chiang, Chih-Chao ^{[1
,2
,3
]}

Cheng, Wei-Jen ^{[1
,4
,5
]}

Korinek, Michal ^{[6
,7
,8
,9
]}

Lin, Cheng-Yu ^{[6
]}

Hwang, Tsong-Long ^{[4
,6
,7
,8
,10
,11
,12
]}

机构：

[1] Chang Gung Univ, Grad Inst Clin Med Sci, Coll Med, Taoyuan, Taiwan

[2] Taoyuan Chinese Med Assoc, Supervisor Board, Taoyuan, Taiwan

[3] Puxin Fengze Chinese Med Clin, Taoyuan, Taiwan

[4] Chang Gung Univ, Sch Tradit Chinese Med, Taoyuan, Taiwan

[5] Chang Gung Mem Hosp, Ctr Tradit Chinese Med, Taoyuan, Taiwan

[6] Chang Gung Univ, Grad Inst Nat Prod, Coll Med, Taoyuan, Taiwan

[7] Chang Gung Univ Sci & Technol, Res Ctr Food & Cosmet Safety, Res Ctr Chinese Herbal Med, Taoyuan, Taiwan

[8] Chang Gung Univ Sci & Technol, Grad Inst Hlth Ind Technol, Taoyuan, Taiwan

[9] Kaohsiung Med Univ, Dept Biotechnol, Coll Life Sci, Kaohsiung, Taiwan

[10] Chang Gung Univ, Hlth Aging Res Ctr, Chinese Herbal Med Res Team, Taoyuan, Taiwan

[11] Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan, Taiwan

[12] Ming Chi Univ Technol, Dept Chem Engn, New Taipei, Taiwan

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷

关键词：

neutrophils; psoriasis; immunity; respiratory burst; degranulation; neutrophil extracellular traps; EXTRACELLULAR TRAP FORMATION; DENDRITIC CELLS; ATOPIC-DERMATITIS; OXIDATIVE STRESS; ECONOMIC BURDEN; MAST-CELLS; MYELOPEROXIDASE; INFLAMMATION; RELEASE; KERATINOCYTES;

D O I：

10.3389/fimmu.2019.02376

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutrophils are the most abundant innate immune cells. The pathogenic roles of neutrophils are related to chronic inflammation and autoimmune diseases. Psoriasis is a chronic systemic inflammatory disease affecting similar to 2-3% of the world population. The abundant presence of neutrophils in the psoriatic skin lesions serves as a typical histopathologic hallmark of psoriasis. Recent reports indicated that oxidative stress, granular components, and neutrophil extracellular traps from psoriatic neutrophils are related to the initial and maintenance phases of psoriasis. This review provides an overview on the recent (up to 2019) advances in understanding the role of neutrophils in the pathophysiology of psoriasis, including the effects of respiratory burst, degranulation, and neutrophil extracellular trap formation on psoriatic immunity and the clinical relationships.

引用

页数：12

共 153 条

[81] Neutrophil Extracellular Traps Induce Human Th17 Cells: Effect of Psoriasis-Associated TRAF3IP2 Genotype [J].