Role of Kisspeptin/GPR54 System in Human Reproductive Axis

被引：0
作者：
Silveira, Leticia F. G. [1 ]
Teles, Milena G. [1 ]
Trarbach, Ericka B. [1 ]
Latronico, Ana Claudia [1 ]
机构：
[1] Univ Sao Paulo, Fac Med, Hosp Clin,Unidade Endocrinol Desenvolvimento, Disciplina Endocrinol & Metabol,Lab Hormonios & G, BR-05403900 Sao Paulo, Brazil
来源：
KALLMANN SYNDROME AND HYPOGONADOTROPIC HYPOGONADISM | 2010年 / 39卷
关键词：
GONADOTROPIN-RELEASING-HORMONE; MONKEY MACACA-MULATTA; PROTEIN-COUPLED RECEPTOR; HYPOGONADOTROPIC HYPOGONADISM; LUTEINIZING-HORMONE; KISS-1; GENE; GPR54; ACTIVATION; PEPTIDE;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The kisspeptin-GPR54 signaling complex is a key gatekeeper of human sexual maturation. Kisspeptins, encoded by the KISS! gene, constitute a powerful stimulus for gonadotropin-releasing hormone-induced gonadotropin secretion. In addition, the KISS? gene is a target for regulation by gonadal steroids in both sexes. The increase in hypothalamic kisspeptin expression at puberty is believed to contribute to maturation of the reproductive axis. Homozygous or compound heterozygous loss-of-function mutations in the GPR54 gene have been identified in familial and sporadic patients with isolated hypogonadotropic hypogonadism without olfactory abnormalities. In addition, mice with targeted deletions of Kiss? or Gpr54 have a similar failure of sexual maturation. Study of these mutations provides an important contribution in the understanding of the role of the kisspeptin/GPR54 system in the control of human puberty development and reproductive function. Copyright (C) 2010 S. Karger AG, Basel
引用
收藏
页码：13 / 24
页数：12
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