How cocrystals of weakly basic drugs and acidic coformers might modulate solubility and stability

被引：52

作者：

Kuminek, G. ^{[1
]}

Rodriguez-Hornedo, N. ^{[1
]}

Siedler, S. ^{[2
]}

Rocha, H. V. A. ^{[3
]}

Cuffini, S. L. ^{[2
,4
]}

Cardoso, S. G. ^{[2
]}

机构：

[1] Univ Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA

[2] Univ Fed Santa Catarina, Qual Control Lab, Post Grad Program Pharm, Florianopolis, SC, Brazil

[3] Fundacao Oswaldo Cruz, Farmanguinhos, Lab Adv Pharmaceut Syst, Rio De Janeiro, RJ, Brazil

[4] Univ Fed Sao Paulo, Inst Sci & Technol, Post Grad Program Mat Sci & Engn, Sao Paulo, SP, Brazil

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 34期

基金：

美国国家卫生研究院;

关键词：

NEVIRAPINE; PH; DISSOLUTION; MEDIA;

D O I：

10.1039/c6cc00898d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cocrystals of a weakly basic drug (nevirapine) with acidic coformers are shown to alter the solubility dependence on pH, and to exhibit a pH(max) above which a less soluble cocrystal becomes more soluble than the drug. The cocrystal solubility advantage can be dialed up or down by solution pH.

引用

页码：5832 / 5835

页数：4

共 20 条

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