APOE4 provokes tau aggregation via inhibition of noradrenaline transport

被引：3
|
作者：
Lempriere, Sarah
机构：
来源：
NATURE REVIEWS NEUROLOGY | 2021年 / 17卷 / 06期
关键词：
D O I：
10.1038/s41582-021-00511-x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
引用
收藏
页码：328 / 328
页数：1
相关论文
共 50 条
  • [41] Repetitive head trauma and apoE4 induce chronic cerebrovascular alterations that impair tau elimination from the brain
    Eisenbaum, Maxwell
    Pearson, Andrew
    Ortiz, Camila
    Koprivica, Milica
    Cembran, Arianna
    Mullan, Michael
    Crawford, Fiona
    Ojo, Joseph
    Bachmeier, Corbin
    EXPERIMENTAL NEUROLOGY, 2024, 374
  • [42] Possible Role of Tau in Mediating Pathological Effects of apoE4 in vivo prior to and following Activation of the Amyloid Cascade
    Inbar, Dafna
    Belinson, Haim
    Rosenman, Hanna
    Michaelson, Daniel M.
    NEURODEGENERATIVE DISEASES, 2010, 7 (1-3) : 16 - 23
  • [43] Alzheimer A beta neurotoxicity: Promotion by antichymotrypsin, ApoE4; Inhibition by A beta-related peptides
    Ma, JY
    Brewer, HB
    Potter, H
    NEUROBIOLOGY OF AGING, 1996, 17 (05) : 773 - 780
  • [44] A glycan epitope correlates with tau in serum and predicts progression to Alzheimer's disease in combination with APOE4 allele status
    Zhou, Robin Ziyue
    Vetrano, Davide Liborio
    Grande, Giulia
    Duell, Frida
    Jonsson, Linus
    Laukka, Erika J.
    Fredolini, Claudia
    Winblad, Bengt
    Tjernberg, Lars
    Schedin-Weiss, Sophia
    ALZHEIMERS & DEMENTIA, 2023, 19 (07) : 3244 - 3249
  • [45] Diabetes mellitus contributes to higher cerebrospinal fluid tau levels selectively in Alzheimer's disease patients with the APOE4 genotype
    Motta, Caterina
    Assogna, Martina
    Bonomi, Chiara Giuseppina
    Mascolo, Alfredo Paolo
    De Lucia, Vincenzo
    Semprini, Roberta
    Mercuri, Nicola Biagio
    Koch, Giacomo
    Martorana, Alessandro
    EUROPEAN JOURNAL OF NEUROLOGY, 2021, 28 (12) : 3965 - 3971
  • [46] Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia
    Wang, Chao
    Xiong, Monica
    Gratuze, Maud
    Bao, Xin
    Shi, Yang
    Andhey, Prabhakar Sairam
    Manis, Melissa
    Schroeder, Caitlin
    Yin, Zhuoran
    Madore, Charlotte
    Butovsky, Oleg
    Artyomov, Maxim
    Ulrich, Jason D.
    Holtzman, David M.
    NEURON, 2021, 109 (10) : 1657 - +
  • [47] Functional Brain Network Connectivity Patterns Associated With Normal Cognition at Old-Age, Local β-amyloid, Tau, and APOE4
    Quevenco, Frances C.
    van Bergen, Jiri M.
    Treyer, Valerie
    Studer, Sandro T.
    Kagerer, Sonja M.
    Meyer, Rafael
    Gietl, Anton F.
    Kaufmann, Philipp A.
    Nitsch, Roger M.
    Hock, Christoph
    Unschuld, Paul G.
    FRONTIERS IN AGING NEUROSCIENCE, 2020, 12
  • [48] APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes (vol 570, pg 332, 2019)
    Blanchard, Joel W.
    Akay, Leyla Anne
    Davila-Velderrain, Jose
    von Maydell, Djuna
    Mathys, Hansruedi
    Davidson, Shawn M.
    Effenberger, Audrey
    Chen, Chih-Yu
    Maner-Smith, Kristal
    Hajjar, Ihab
    Ortlund, Eric A.
    Bula, Michael
    Agbas, Emre
    Ng, Ayesha
    Jiang, Xueqiao
    Kahn, Martin
    Blanco-Duque, Cristina
    Lavoie, Nicolas
    Liu, Liwang
    Reyes, Ricardo
    Lin, Yuan-Ta
    Ko, Tak
    R'Bibo, Lea
    Ralvenius, William T.
    Bennett, David A.
    Cam, Hugh P.
    Kellis, Manolis
    Tsai, Li-Huei
    NATURE, 2024, : E9 - E9
  • [49] Drugs targeting APOE4 that regulate beta-amyloid aggregation in the brain: Therapeutic potential for Alzheimer's disease
    Poblano, Joan
    Castillo-Tobias, Ileana
    Berlanga, Lia
    Tamayo-Ordonez, Maria Concepcion
    Rodriguez-Salazar, Maria del Carmen
    Silva-Belmares, Sonia Yesenia
    Aguayo-Morales, Hilda
    Cobos-Puc, Luis E.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2024, 135 (03) : 237 - 249
  • [50] Microglial APOE4 promotes neuron degeneration in Alzheimer's disease through inhibition of lipid droplet autophagy
    Mao, Meng
    Ma, Xiwen
    Wang, Xiaochuan
    Ye, Jianping
    ACTA PHARMACEUTICA SINICA B, 2025, 15 (01) : 657 - 660
12345