The effects of anodal tDCS over the supplementary motor area on gait initiation in Parkinson's disease with freezing of gait: a pilot study

被引:38
作者
Lu, Chiahao [1 ]
Huffmaster, Sommer L. Amundsen [1 ]
Tuite, Paul J. [1 ]
MacKinnon, Colum D. [1 ]
机构
[1] Univ Minnesota, Dept Neurol, Minneapolis, MN 55414 USA
基金
美国国家卫生研究院;
关键词
Transcranial direct current stimulation (tDCS); Supplementary motor area (SMA); Parkinson's disease; Freezing of gait (FOG); Gait initiation; DIRECT-CURRENT STIMULATION; ANTICIPATORY POSTURAL ADJUSTMENTS; TRANSCRANIAL MAGNETIC STIMULATION; EXTERNALLY TRIGGERED MOVEMENTS; CEREBRAL-BLOOD-FLOW; STEP INITIATION; SMA; PREDICTABILITY; EXCITABILITY; POTENTIALS;
D O I
10.1007/s00415-018-8953-1
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective We investigated if anodal transcranial direct current stimulation (A-tDCS), applied over the supplementary motor areas (SMAs), could improve gait initiation in Parkinson's disease (PD) with freezing of gait (FOG). Methods In this double-blinded cross-over pilot study, ten PD with FOG underwent two stimulation sessions: A-tDCS (1 mA, 10 min) and sham stimulation. Eight blocks of gait initiation were collected per session: (1) pre-tDCS, with acoustic cueing; (2) pre-tDCS, self-initiated (no cue); and (3-8) post-tDCS, self-initiated. Gait initiation kinetics were analyzed with two-way repeated measures ANOVAs for the effects of A-tDCS. Results A-tDCS did not significantly improve the magnitude or timing of anticipatory postural adjustments or the execution of the first step during self-initiated gait compared with baseline measures (p > .13). The lack of significant change was not due to an inability to generate functional APAs since external cueing markedly improved gait initiation (p < .01). Conclusions A single dose of A-tDCS over the SMAs did not improve self-initiated gait in PD and FOG. Alternative approaches using a different dose or cortical target are worthy of exploration since individuals demonstrated the capacity to improve. Significance Neuromodulation strategies tailored to facilitate SMA activity may be ineffective for the treatment of gait initiation impairment in people with PD and FOG.
引用
收藏
页码:2023 / 2032
页数:10
相关论文
共 50 条
[41]   Pilot study of atomoxetine in patients with Parkinson's disease and dopa-unresponsive Freezing of Gait [J].
Revuelta, Gonzalo J. ;
Embry, Aaron ;
Elm, Jordan J. ;
Gregory, Chris ;
Delambo, Amy ;
Kautz, Steve ;
Hinson, Vanessa K. .
TRANSLATIONAL NEURODEGENERATION, 2015, 4
[42]   The plurality of mechanisms of gait initiation disorders in Parkinson's disease: Relationships with motor, cognitive and limbic functions [J].
Gerard, Morgane ;
Bayot, Madli ;
Dujardin, Kathy ;
Defebvre, Luc ;
Delval, Arnaud .
GAIT & POSTURE, 2024, 113 :407-411
[43]   A pilot study: influence of visual cue color on freezing of gait in persons with Parkinson's disease [J].
Bryant, Mon S. ;
Rintala, Diana H. ;
Lai, Eugene C. ;
Protas, Elizabeth J. .
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY, 2010, 5 (06) :456-461
[44]   Pilot study of atomoxetine in patients with Parkinson’s disease and dopa-unresponsive Freezing of Gait [J].
Gonzalo J. Revuelta ;
Aaron Embry ;
Jordan J. Elm ;
Chris Gregory ;
Amy Delambo ;
Steve Kautz ;
Vanessa K. Hinson .
Translational Neurodegeneration, 4
[45]   Computer-assisted cognitive rehabilitation on freezing of gait in Parkinson's disease: A pilot study [J].
Dibilio, Valeria ;
Nicoletti, Alessandra ;
Mostile, Giovanni ;
Portaro, Giacomo ;
Luca, Antonina ;
Patti, Francesco ;
Zappia, Mario .
NEUROSCIENCE LETTERS, 2017, 654 :38-41
[46]   Gait initiation impairments in both Essential Tremor and Parkinson's disease [J].
Fernandez, Kristina M. ;
Roemmich, Ryan T. ;
Stegemoeller, Elizabeth L. ;
Amano, Shinichi ;
Thompson, Amanda ;
Okun, Michael S. ;
Hass, Chris J. .
GAIT & POSTURE, 2013, 38 (04) :956-961
[47]   Anodal tDCS modulates cortical activity and synchronization in Parkinson's disease depending on motor processing [J].
Schoellmann, Anna ;
Scholten, Marlieke ;
Wasserka, Barbara ;
Govindan, Rathinaswamy B. ;
Krueger, Rejko ;
Gharabaghi, Alireza ;
Plewnia, Christian ;
Weiss, Daniel .
NEUROIMAGE-CLINICAL, 2019, 22
[48]   Progression of postural control and gait deficits in Parkinson's disease and freezing of gait: A longitudinal study [J].
Vervoort, Griet ;
Bengevoord, Aniek ;
Strouwen, Carolien ;
Bekkers, Esther M. J. ;
Heremans, Elke ;
Vandenberghe, Wim ;
Nieuwboer, Alice .
PARKINSONISM & RELATED DISORDERS, 2016, 28 :73-79
[49]   PROPRIOCEPTIVE DEFICITS IN PARKINSON'S DISEASE PATIENTS WITH FREEZING OF GAIT [J].
Tan, T. ;
Almeida, Q. J. ;
Rahimi, F. .
NEUROSCIENCE, 2011, 192 :746-752
[50]   Freezing of Gait in Parkinson's Disease: Invasive and Noninvasive Neuromodulation [J].
Rahimpour, Shervin ;
Gaztanaga, Wendy ;
Yadav, Amol P. ;
Chang, Stephano J. ;
Krucoff, Max O. ;
Cajigas, Iahn ;
Turner, Dennis A. ;
Wang, Doris D. .
NEUROMODULATION, 2021, 24 (05) :829-842