Evaluation of Dementia Rating Scales in Parkinson's Disease Dementia

被引：12

作者：

Harvey, Philip D. ^{[1
]}

Ferris, Steven H. ^{[2
,3
]}

Cummings, Jeffrey L. ^{[4
]}

Wesnes, Keith A. ^{[5
]}

Hsu, Chuanchieh ^{[6
]}

Lane, Roger M. ^{[6
]}

Tekin, Sibel ^{[6
]}

机构：

[1] Emory Univ, Sch Med, Atlanta, GA 30322 USA

[2] NYU, Sch Med, Rush Alzheimers Dis Ctr, New York, NY USA

[3] Nathan Kline Inst Orange Burg, New York, NY USA

[4] Univ Calif Los Angeles, Mary S Easton Ctr Alzheimers Dis Res, Los Angeles, CA USA

[5] Cognit Drug Res Ltd, Goring On Thames, England

[6] Novartis Pharmaceut, E Hanover, NJ USA

来源：

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS | 2010年 / 25卷 / 02期

关键词：

dementia assessment scales; Parkinson's disease dementia; validity; reliability; MONTREAL COGNITIVE ASSESSMENT; ALZHEIMERS-DISEASE; CLINICAL-DIAGNOSIS; RIVASTIGMINE; IMPAIRMENT; INVENTORY;

D O I：

10.1177/1533317509333904

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Disease-specific assessments are not currently available for patients with Parkinson's disease dementia (PDD). This study evaluated the criterion-related validity and test-retest reliability of the Alzheimer's Disease Assessment scale cognitive subscale (ADAS-cog) in terms of sensitivity for differentiation between mild and moderate severity impairment in PDD. Six other dementia rating scales and cognitive tests were also examined. A total of 113 patients with PDD or Alzheimer disease were recruited into this 4-week, multicenter study, segregated into 2 severity groups based on Mini-Mental State Examination (MMSE) score. Mean ADAS-cog scores showed a statistically significant separation between mild and moderate severity patients in both dementias (P < .001). For the ADAS-cog, test-retest Spearman correlation coefficients were significant for each dementia type and severity. This study demonstrated the criterion-related validity and test-retest reliability for ADAS-cog in patients with PDD and strong correlations with MMSE. This supports the validity of previous results obtained with these measures in studies of patients with PDD.

引用

页码：142 / 148

页数：7

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