Long non-coding RNA MVIH is associated with poor prognosis and malignant biological behavior in breast cancer

被引：43

作者：

Lei, Bo ^{[1
]}

Xu, Shou-ping ^{[1
]}

Liang, Xiao-shuan ^{[1
]}

Li, Yi-wen ^{[2
]}

Zhang, Jin-feng ^{[1
]}

Zhang, Guo-qiang ^{[1
]}

Pang, Da ^{[1
]}

机构：

[1] Harbin Med Univ, Canc Hosp, Dept Breast Surg, 150 Haping Rd, Harbin 150086, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 2, Dept Med Oncol, 148 Baojian Rd, Harbin 150086, Peoples R China

来源：

TUMOR BIOLOGY | 2016年 / 37卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Breast cancer; Long non-coding RNA; MVIH; Prognosis; Biomarker; TUMOR-GROWTH; CODING RNA; PROLIFERATION; METASTASIS; EXPRESSION; INVASION;

D O I：

10.1007/s13277-015-4360-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In recent years, with the development of transcriptomics, the effect of long non-coding RNAs (LncRNAs) on the regulation of biological processes is being elucidated. LncRNAs play an important role in tumor occurrence and development. LncRNA associated with microvascular invasion in hepatocellular carcinoma (LncRNA MVIH) was first identified in hepatocellular carcinoma and is associated with angiogenesis, tumor growth and metastasis upregulation, and poor recurrence-free survival. MVIH has an important role in non-small cell lung cancer, in which it promotes cell proliferation and metastasis, and high MVIH expression indicates poor overall survival. However, the involvement of MVIH in breast cancer is unclear. Our research revealed that the expression levels of MVIH in breast cancer tissues were higher than in adjacent noncancerous tissues, and high MVIH expression was correlated with Ki67 expression. Moreover, breast cancer patients with high MVIH expression levels showed poor overall survival and disease-free survival. Multivariate analysis results indicated that MVIH was an independent prognostic factor in breast cancer. In addition, upregulated MVIH expression levels promoted cell proliferation and cell cycle, and inhibited cell apoptosis, while reduced MVIH expression showed the converse. In summary, our findings suggest that MVIH may have an important role in breast cancer and may serve as a new biomarker and a potential therapeutic target.

引用

页码：5257 / 5264

页数：8

共 23 条

[1] Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers [J].

Brunner, Alayne L. ;

Beck, Andrew H. ;

Edris, Badreddin ;

Sweeney, Robert T. ;

Zhu, Shirley X. ;

Li, Rui ;

Montgomery, Kelli ;

Varma, Sushama ;

Gilks, Thea ;

Guo, Xiangqian ;

Foley, Joseph W. ;

Witten, Daniela M. ;

Giacomini, Craig P. ;

Flynn, Ryan A. ;

Pollack, Jonathan R. ;

Tibshirani, Robert ;

Chang, Howard Y. ;

van de Rijn, Matt ;

West, Robert B. .

GENOME BIOLOGY, 2012, 13 (08) :R75

[2] Breast Cancer Statistics, 2013 [J].

DeSantis, Carol ;

Ma, Jiemin ;

Bryan, Leah ;

Jemal, Ahmedin .

CA-A CANCER JOURNAL FOR CLINICIANS, 2014, 64 (01) :52-62

[3] Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis [J].

Gupta, Rajnish A. ;

Shah, Nilay ;

Wang, Kevin C. ;

Kim, Jeewon ;

Horlings, Hugo M. ;

Wong, David J. ;

Tsai, Miao-Chih ;

Hung, Tiffany ;

Argani, Pedram ;

Rinn, John L. ;

Wang, Yulei ;

Brzoska, Pius ;

Kong, Benjamin ;

Li, Rui ;

West, Robert B. ;

van de Vijver, Marc J. ;

Sukumar, Saraswati ;

Chang, Howard Y. .

NATURE, 2010, 464 (7291) :1071-U148

[4] The hallmarks of cancer A long non-coding RNA point of view [J].

Gutschner, Tony ;

Diederichs, Sven .

RNA BIOLOGY, 2012, 9 (06) :703-719

[5] Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1) [J].

Huang, J. ;

Zhou, N. ;

Watabe, K. ;

Lu, Z. ;

Wu, F. ;

Xu, M. ;

Mo, Y-Y .

CELL DEATH & DISEASE, 2014, 5 :e1008-e1008

[6] Large non-coding RNAs: missing links in cancer? [J].

Huarte, Maite ;

Rinn, John L. .

HUMAN MOLECULAR GENETICS, 2010, 19 :R152-R161

[7]

Jonsson P, 2015, MOL ENDOCRINOL

[8] lncRNAs: Insights into their function and mechanics in underlying disorders [J].

Li, Xiaolei ;

Wu, Zhiqiang ;

Fu, Xiaobing ;

Han, Weidong .

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 2014, 762 :1-21

[9] Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1 [J].

Liu, Ruilei ;

Li, Jie ;

Lai, Yuanhui ;

Liao, Yi ;

Liu, Ruiming ;

Qiu, Wanshou .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2015, 81 :491-497

[10] GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer [J].

Mourtada-Maarabouni, M. ;

Pickard, M. R. ;

Hedge, V. L. ;

Farzaneh, F. ;

Williams, G. T. .

ONCOGENE, 2009, 28 (02) :195-208

← 1 2 3 →