Intestinal pathophysiological and microbial changes in sickle cell disease: Potential targets for therapeutic intervention

被引：19

作者：

Dutta, Dibyendu ^{[1
]}

Aujla, Amandeep ^{[1
]}

Knoll, Bettina M. ^{[2
]}

Lim, Seah H. ^{[1
,3
]}

机构：

[1] New York Med Coll, Dept Med, Div Hematol & Oncol, Valhalla, NY 10595 USA

[2] New York Med Coll, Dept Med, Div Infect Dis, Valhalla, NY 10595 USA

[3] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2020年 / 188卷 / 04期

关键词：

Sickle cell disease; intestinal microbial changes; intestinal injury; intestinal permeability; vaso-occlusive crisis; NEUTROPHIL ACTIVATION; GUT PERMEABILITY; CARE UTILIZATION; MORTALITY; PREVENTION; BACTERIA; BARRIER; ANEMIA; MODEL;

D O I：

10.1111/bjh.16273

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is a large therapeutic gap in the treatment of sickle cell disease (SCD). Recent studies demonstrated the presence of pathophysiological and microbial changes in the intestine of patients with SCD. The intestinal microbes have also been found to regulate neutrophil ageing and possible basal activation of circulating neutrophils. Both aged and activated neutrophils are pivotal for the pathogenesis of vaso-occlusive crisis in SCD. In this paper, we will provide an overview of the intestinal pathophysiological and microbial changes in SCD. Based on these changes, we will propose therapeutic approaches that could be investigated for treating SCD.

引用

页码：488 / 493

页数：6

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