Expression of the HLA-C2-specific activating killer-cell Ig-like receptor KIR2DS1 on NK and T cells

被引:21
|
作者
Cognet, Celine [1 ,2 ,3 ,4 ]
Farnarier, Catherine [4 ]
Gauthier, Laurent [5 ]
Frassati, Coralie [7 ]
Andre, Pascale [5 ]
Magerus-Chatinet, Aude [6 ]
Anfossi, Nicolas [5 ]
Rieux-Laucat, Frederic [6 ]
Vivier, Eric [1 ,2 ,3 ,4 ]
Schleinitz, Nicolas [1 ,4 ]
机构
[1] Univ Aix Marseille 2, Ctr Immunol Marseille Luminy, F-13288 Marseille, France
[2] INSERM, UMR 6312, F-75654 Paris 13, France
[3] CNRS, UMR6102, F-75700 Paris, France
[4] Hop Conception, Assistance Publ Hop Marseille, F-13385 Marseille, France
[5] Innate Pharma SA, Marseille, France
[6] Univ Paris 05, INSERM, U768, F-75270 Paris 06, France
[7] Etab Francais du Sang, F-13385 Marseille, France
关键词
NK cells; KIRs; 2DS1; 2DL1; KIR plus T cells; MHC CLASS-I; IMMUNOGLOBULIN-LIKE RECEPTORS; INHIBITORY RECEPTORS; PSORIASIS-VULGARIS; MOLECULES; KIR3DS1; GENE; TRANSPLANTATION; SUSCEPTIBILITY; ASSOCIATION;
D O I
10.1016/j.clim.2009.12.009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Killer Ig-like receptors (KIRs) are MHC class I-specific receptors expressed by Natural Killer (NK) and T cell subsets. KIRs either inhibit (KIR-L) or activate (KIR-S) lymphocyte functions. Inhibitory KIR2DL1 and activating KIR2DS1 share ligand specificity for the HLA-C2 group, consistent with their almost identical extracytoplasmic domain. This homology hampered the distinction between KIR2DL1 and KIR2DS1. We report here the characterization of the KIR2DS1(+) subsets among primary human NK and T cells. Regardless of the host HLA-C genotype, around 10% of circulating NK cells expressed KIR2DS1 in absence of KIR2DL1. In HLA-C2 individuals, KIR2DS1 was not able to induce NK cell education (i.e., the acquisition of NK cell competence) nor to interfere with KIR2DL1-induced NK cell education. KIR2DS1 was also present on rare oligoclonal TCR alpha beta(+)CD8 alpha(+) and TCR alpha beta(+)CD4(-)CD8(-) subsets. As KIR2DS1 has been associated with autoimmunity and hematopoietic stem cell transplantation, these results pave the way to dissect the function of KIR2DS1 in these clinical conditions. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:26 / 32
页数:7
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