Midlife predictors of Alzheimer's disease

被引：47
作者：
Bendlin, B. B. [1 ,2 ]
Carlsson, C. M. [1 ,2 ]
Gleason, C. E. [1 ,2 ]
Johnson, S. C. [1 ,2 ]
Sodhi, A. [1 ,2 ]
Gallagher, C. L. [1 ,2 ]
Puglielli, L. [1 ,2 ]
Engelman, C. D. [3 ]
Ries, M. L. [1 ,2 ]
Xu, G. [1 ,2 ]
Wharton, W. [1 ,2 ]
Asthana, S. [1 ,2 ]
机构：
[1] William S Middleton Mem Vet Adm Med Ctr, Geriatr Res Educ & Clin Ctr, Madison, WI USA
[2] Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Madison, WI USA
[3] Univ Wisconsin, Dept Populat Hlth Sci, Sch Med & Publ Hlth, Madison, WI USA
来源：
MATURITAS | 2010年 / 65卷 / 02期
关键词：
Alzheimer's disease; Dementia; Midlife; Genes; Family history; Estrogen; Vascular risk; Education; MRI; APOLIPOPROTEIN-E EPSILON-4; ESTROGEN REPLACEMENT THERAPY; GENOME-WIDE ASSOCIATION; SYSTOLIC BLOOD-PRESSURE; WHITE-MATTER INTEGRITY; HEALTH INITIATIVE WHI; WOMENS HEALTH; COGNITIVE FUNCTION; PHYSICAL-ACTIVITY; POSTMENOPAUSAL WOMEN;
D O I：
10.1016/j.maturitas.2009.12.014
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Factors contributing to increased risk for Alzheimer's disease (AD) include age, sex, genes, and family history of AD. Several risk factors for AD are endogenous; however, accumulating evidence implicates modifiable risk factors in the pathogenesis of AD. Although the continued task of identifying new genes will be critical to learning more about the disease, several research findings suggest that potentially alterable environmental factors influence genetic contributions, providing targets for disease prevention and treatment. Here, we review midlife risk factors for AD, and address the potential for therapeutic intervention in midlife. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：131 / 137
页数：7
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