The gut microbiome as a modulator of healthy ageing

被引：421

作者：

Ghosh, Tarini Shankar ^{[1
,2
]}

Shanahan, Fergus ^{[1
,3
]}

O'Toole, Paul W. ^{[1
,2
]}

机构：

[1] Natl Univ Ireland, Univ Coll Cork, APC Microbiome Ireland, Cork, Ireland

[2] Natl Univ Ireland, Univ Coll Cork, Sch Microbiol, Cork, Ireland

[3] Natl Univ Ireland, Univ Coll Cork, Dept Med, Cork, Ireland

来源：

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2022年 / 19卷 / 09期

关键词：

CLOSTRIDIUM-DIFFICILE INFECTION; TRIMETHYLAMINE-N-OXIDE; BACILLUS-COAGULANS GBI-30; IRRITABLE-BOWEL-SYNDROME; FECAL MICROBIOTA; OLDER-ADULTS; DOUBLE-BLIND; INFLUENZA VACCINATION; DEPENDENT METABOLITE; MEDITERRANEAN DIET;

D O I：

10.1038/s41575-022-00605-x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The gut microbiome is a contributory factor in ageing-related health loss and in several non-communicable diseases in all age groups. Some age-linked and disease-linked compositional and functional changes overlap, while others are distinct. In this Review, we explore targeted studies of the gut microbiome of older individuals and general cohort studies across geographically distinct populations. We also address the promise of the targeted restoration of microorganisms associated with healthier ageing. In this Review, O'Toole and colleagues discuss the composition and function of the gut microbiome as it relates to ageing and 'unhealthy' ageing as well as the potential for microbiome-directed interventions to encourage 'healthy' ageing.

引用

页码：565 / 584

页数：20

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