Six-Month Comparative Analysis Monitoring the Progression of the Largest Diameter of the Sweating Inhibition Halo of Different Botulinum Toxins Type-A

Background: Excessive sweating is a clinical condition that can be improved with type-A botulinum toxin (BTX-A). Objectives: To evaluate and compare the largest diameter of sweating inhibition halo (SIH) of 5 different commercially available BTX-A, in five different doses, in a 6-month-long clinical evaluation. Methods: Twenty-five adult female volunteers were injected in the dorsal trunk area with both 100 units (100UI) and 500 units (500UI) BTX-A products, reconstituted in a ratio of 1:2.5 IU, respectively. Products were applied in five different concentrations (1:2.5U, 2:5U, 3:7.5U, 4:10U, and 5:12.5U). After 30, 60, 90, 120, 150, and 180 days, a starch-iodine test was performed to obtain the largest diameter of each SIH. Results: The higher the number of units used, the larger the SIH p < 0.05 for all BTX-A. However, Botox (R), Botulift (R), Dysport (R), and Prosigne (R) have pretty likewise SIH along the study, with some few differences for some doses and months between one and another. However, Xeomin (R) is the BTX-A with the smallest SIH, in comparison with all others, in any dose and period. Conclusions: Differences were observed among all brands of BTX-As, based on dose and time after injection. Xeomin (R) provides the smallest SIH in comparison with others BTX-A.