NOTCH signaling pathway and non-coding RNAs in cancer

被引：28
作者：
Guo, Jing [1 ]
Li, Ping [1 ]
Liu, Xiaomin [1 ]
Li, Yanli [1 ]
机构：
[1] Shanghai Univ, Sch Life Sci, Lab Noncoding RNA & Canc, Shanghai 200444, Peoples R China
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2019年 / 215卷 / 11期
关键词：
Non-coding RNA; Notch signaling; Cancer; INHIBITS CELL-PROLIFERATION; RESISTANT PROSTATE-CANCER; COLORECTAL-CANCER; UP-REGULATION; CIRCULAR RNA; STEM-CELL; BREAST-CANCER; LUNG-CANCER; MICRORNA-34A SUPPRESSES; GASTRIC-CANCER;
D O I：
10.1016/j.prp.2019.152620
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Malignant tumors, known as cancer, seriously threaten human life and health. Cancer has the characteristics of abnormal cell differentiation, proliferation, invasion and metastasis. As a result, cancer often accompanied by poor prognosis and a lower survival rate. Notch signaling pathway is a highly conserved system in many multicellular organisms, and which has been proved to play a biological role in many cancers. In recent years, increasing evidence has shown that non-coding RNA can not only activate or inhibit NOTCH pathway, but also regulate the occurrence and development of cancer through NOTCH pathway. Therefore, we focus on the cancer-NOTCH-non-coding RNA axis in this review, and provide new ideas for cancer therapy.
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页数：7
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