Risk of Coronavirus Disease 2019 Occurrence, Severe Presentation, and Mortality in Patients with Lung Cancer

被引：6

作者：

Yang, Bumhee ^{[1
]}

Choi, Hayoung ^{[2
]}

Lee, Sun-Kyung ^{[3
,4
]}

Chung, Sung Jun ^{[3
]}

Yeo, Yoomi ^{[3
]}

Shin, Yoon Mi ^{[1
]}

Park, Dong Won ^{[3
]}

Park, Tai Sun ^{[3
]}

Moon, Ji-Yong ^{[3
]}

Kim, Tae-Hyung ^{[3
]}

Sim, Yun Su ^{[2
]}

Yoon, Ho Joo ^{[3
]}

Sohn, Jang Won ^{[3
]}

Lee, Hyun ^{[3
]}

Kim, Sang-Heon ^{[3
]}

机构：

[1] Chungbuk Natl Univ, Chungbuk Natl Univ Hosp, Dept Med, Div Pulm & Crit Care Med,Coll Med, Cheongju, South Korea

[2] Hallym Univ, Kangnam Sacred Heart Hosp, Dept Internal Med, Div Pulm Allergy & Crit Care Med,Coll Med, Seoul, South Korea

[3] Hanyang Univ, Dept Internal Med, Div Pulm Med & Allergy, Coll Med, 222 Wangsimni Ro, Seoul 04763, South Korea

[4] Hanyang Univ, Coll Nat Sci, Dept Math, Seoul, South Korea

来源：

CANCER RESEARCH AND TREATMENT | 2021年 / 53卷 / 03期

关键词：

COVID-19; Lung neoplasms; Mortality; COVID-19;

D O I：

10.4143/crt.2020.1242

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose This study aimed to analyze whether patients with lung cancer have a higher susceptibility of coronavirus disease 2019 (COVID-19), severe presentation, and higher mortality than those without lung cancer. Materials and Methods A nationwide cohort of confirmed COVID-19 (n=8,070) between January 1, 2020, and May 30, 2020, and a 1:15 age-, sex-, and residence-matched cohort (n=121,050) were constructed. A nested case-control study was performed to compare the proportion of patients with lung cancer between the COVID-19 cohort and the matched cohort. Results The proportion of patients with lung cancer was significantly higher in the COVID-19 cohort (0.5% [37/8,070]) than in the matched cohort (0.3% [325/121,050]) (p=0.002). The adjusted odds ratio [OR] of having lung cancer was significantly higher in the COVID-19 cohort than in the matched cohort (adjusted OR, 1.51; 95% confidence interval [CI], 1.05 to 2.10). Among patients in the COVID-19 cohort, compared to patients without lung cancer, those with lung cancer were more likely to have severe COVID-19 (54.1% vs. 13.2%, p < 0.001), including mortality (18.9% vs. 2.8%, p < 0.001). The adjusted OR for the occurrence of severe COVID-19 in patients with lung cancer relative to those without lung cancer was 2.24 (95% CI, 1.08 to 4.74). Conclusion The risk of COVID-19 occurrence and severe presentation, including mortality, may be higher in patients with lung cancer than in those without lung cancer.

引用

页码：678 / 684

页数：7

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