AAV-mediated gene therapy as a strategy to fight obesity and metabolic diseases

被引：14

作者：

Sponton, Carlos Henrique ^{[1
,2
,3
]}

Kajimura, Shingo ^{[1
,2
,3
]}

机构：

[1] UCSF Diabet Ctr, San Francisco, CA 94143 USA

[2] Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94131 USA

[3] Univ Calif San Francisco, Dept Cell & Tissue Biol, San Francisco, CA 94143 USA

来源：

EMBO MOLECULAR MEDICINE | 2018年 / 10卷 / 08期

关键词：

ENERGY-EXPENDITURE; FGF21; THERMOGENESIS;

D O I：

10.15252/emmm.201809431

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The fibroblast growth factor 21 (FGF21) is a member of the FGF superfamily that now comprises 22 members identified in humans. Unlike the canonical role of most FGF family members, FGF21 is released into the circulation and acts as an endocrine hormone by binding with low affinity to FGF receptors (FGFRs) as well as to the co-receptor -klotho in the target cells to trigger the ERK1/2 and MAPKs signaling pathways. Described initially as a hepatokine, subsequent studies identified significant amounts of FGF21 transcript in the pancreas, the adipose tissue, and the skeletal muscle. FGF21 expression is highly regulated by environmental stimuli such as starvation, ketogenic diet, cold exposure, and exercise.

引用

页数：3

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