Microrheology with Optical Tweezers: Measuring the relative viscosity of solutions 'at a glance'

被引：58

作者：

Tassieri, Manlio ^{[1
]}

Del Giudice, Francesco ^{[2
]}

Robertson, Emma J. ^{[3
]}

Jain, Neena ^{[4
]}

Fries, Bettina ^{[4
]}

Wilson, Rab ^{[1
]}

Glidle, Andrew ^{[1
]}

Greco, Francesco ^{[5
]}

Netti, Paolo Antonio ^{[2
]}

Maffettone, Pier Luca ^{[6
]}

Bicanic, Tihana ^{[3
]}

Cooper, Jonathan M. ^{[1
]}

机构：

[1] Univ Glasgow, Sch Engn, Div Biomed Engn, Glasgow G12 8LT, Lanark, Scotland

[2] IIT, Ctr Adv Biomat Hlth Care CRIB, I-80125 Naples, Italy

[3] St Georges Univ London, Dept Infect & Immun, London SW17 0RS, England

[4] Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA

[5] IRC CNR, Ist Ric Combust, I-80125 Naples, Italy

[6] Univ Naples Federico II, Dipartimento Ingn Chim Mat & Prod Ind, I-80125 Naples, Italy

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

英国工程与自然科学研究理事会; 英国惠康基金;

关键词：

ROD-LIKE MACROMOLECULES; VISCOELASTIC MODULI; DYNAMICS; SUSPENSIONS; VISCOMETER; SCATTERING; RHEOLOGY;

D O I：

10.1038/srep08831

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We present a straightforward method for measuring the relative viscosity of fluids via a simple graphical analysis of the normalised position autocorrelation function of an optically trapped bead, without the need of embarking on laborious calculations. The advantages of the proposed microrheology method are evident when it is adopted for measurements of materials whose availability is limited, such as those involved in biological studies. The method has been validated by direct comparison with conventional bulk rheology methods, and has been applied both to characterise synthetic linear polyelectrolytes solutions and to study biomedical samples.

引用

页数：6

共 15 条

[1] Optical tweezers: wideband microrheology
Preece, Daryl
Warren, Rebecca
Evans, R. M. L.
Gibson, Graham M.
Padgett, Miles J.
Cooper, Jonathan M.
Tassieri, Manlio
JOURNAL OF OPTICS, 2011, 13 (04)
[2] Measuring storage and loss moduli using optical tweezers: Broadband microrheology
Tassieri, Manlio
Gibson, Graham M.
Evans, R. M. L.
Yao, Alison M.
Warren, Rebecca
Padgett, Miles J.
Cooper, Jonathan M.
PHYSICAL REVIEW E, 2010, 81 (02):
[3] Linear microrheology with optical tweezers of living cells 'is not an option'!
Tassieri, Manlio
SOFT MATTER, 2015, 11 (29) : 5792 - 5798
[4] Characterizing intracellular mechanics via optical tweezers-based microrheology
Vos, Bart E.
Muenker, Till M.
Betz, Timo
CURRENT OPINION IN CELL BIOLOGY, 2024, 88
[5] Optical tweezers based active microrheology of sodium polystyrene sulfonate (NaPSS)
Chiang, Chia-Chun
Wei, Ming-Tzo
Chen, Yin-Quan
Yen, Pei-Wen
Huang, Yi-Chiao
Chen, Jun-Yeh
Lavastre, Olivier
Guillaume, Husson
Guillaume, Darsy
Chiou, Arthur
OPTICS EXPRESS, 2011, 19 (09): : 8847 - 8854
[6] Microrheology of complex fluids using optical tweezers: a comparison with macrorheological measurements
Pesce, G.
De Luca, A. C.
Rusciano, G.
Netti, P. A.
Fusco, S.
Sasso, A.
JOURNAL OF OPTICS A-PURE AND APPLIED OPTICS, 2009, 11 (03):
[7] Microrheology using dual beam optical tweezers and ultrasensitive force measurements
Knöner, G
Parkin, S
Heckenberg, NR
Rubinsztein-Dunlop, H
NANOMANIPULATION WITH LIGHT, 2005, 5736 : 73 - 80
[8] Single-shot wideband active microrheology using multiple-sinusoid modulated optical tweezers
Kundu, Avijit
Dey, Raunak
Paul, Shuvojit
Banerjee, Ayan
PHYSICAL REVIEW FLUIDS, 2021, 6 (12):
[9] Optical Microrheology of Protein Solutions Using Tailored Nanoparticles
Garting, Tommy
Stradner, Anna
SMALL, 2018, 14 (46)
[10] Living cells as a biological analog of optical tweezers-a non-invasive microrheology approach
Hardiman, William
Clark, Matt
Friel, Claire
Huett, Alan
Perez-Cota, Fernando
Setchfield, Kerry
Wright, Amanda J.
Tassieri, Manlio
ACTA BIOMATERIALIA, 2023, 166 : 317 - 325

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