Association study of schizophrenia spectrum disorders and dopamine D3 receptor gene:: is schizoaffective disorder special?

被引：12
作者：
Meszaros, K
Lenzinger, E
Hornik, K
Füreder, T
Stompe, T
Willinger, U
Heiden, A
Fathi, N
Gerhard, E
Fuchs, K
Sieghart, W
Kasper, S
Aschauer, HN
机构：
[1] Univ Vienna, Hosp Psychiat, Dept Gen Psychiat, A-1090 Vienna, Austria
[2] Vienna Univ Technol, Dept Stat & Probabil Theory, A-1040 Vienna, Austria
[3] Univ Vienna, Hosp Psychiat, Div Biochem Psychiat, A-1090 Vienna, Austria
[4] Univ Vienna, Hosp Psychiat, Dept Social Psychiat, A-1090 Vienna, Austria
来源：
PSYCHIATRY RESEARCH | 2000年 / 96卷 / 02期
关键词：
D3 receptor gene; schizophrenia; schizoaffective disorder; association;
D O I：
10.1016/S0165-1781(00)00209-2
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Alterations in dopamine neurotransmission have been hypothesized to play a role in the etiology of schizophrenia. We considered the dopamine D3 receptor gene on chromosome 3 as a candidate gene for an association analysis. We compared PCR-based genotype markers for healthy controls (n = 120) and patients (n = 95) with schizophrenia and schizophrenia spectrum disorders as diagnosed by consensus according to DSM-III-R. Our results possibly indicate an association of schizoaffective disorder with DRD3 homozygosity (P = 0.056). (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：179 / 183
页数：5
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