Toll-like receptor 3 pathway restricts Marek's disease virus infection

被引：14
|
作者：
Zou, Haitao [1 ,2 ]
Su, Ruixue [1 ,2 ]
Ruan, Jing [1 ,2 ]
Shao, Hongxia [1 ,2 ,3 ]
Qian, Kun [1 ,2 ,3 ]
Ye, Jianqiang [1 ,2 ,3 ]
Qin, Aijian [1 ,2 ,3 ]
机构：
[1] Yangzhou Univ, Key Lab Avian Prevent Med, Minist Educ, Yangzhou 225009, Jiangsu, Peoples R China
[2] Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China
[3] Jiangsu Key Lab Zoonosis, Yangzhou 225009, Jiangsu, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 41期
基金：
中国国家自然科学基金;
关键词：
Marek's disease virus; toll-like receptor 3; poly (I:C); interferon-beta; inflammatory cytokines; HERPES-SIMPLEX-VIRUS; INTERFERON-STIMULATED GENES; BETA INTERFERON; VIRAL PATHOGENESIS; KAPPA-B; ACTIVATION; EXPRESSION; IMMUNITY; CELLS; MODEL;
D O I：
10.18632/oncotarget.20003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Marek's disease virus (MDV) is an alpha-herpesvirus that causes immune suppression and T lymphoma in chickens. Toll-like receptor 3 (TLR3) is critical for the host immune response against MDV infection. Previously, our team demonstrated that pre-treatment of TLR3 agonist poly (I:C) inhibited Marek's disease virus infection in chicken embryo fibroblasts (CEFs). However, whether TLR3 inhibits the aggravation of MDV infection is unknown. In the current study, we found that TLR3 activation in MDV-infected CEFs effectively inhibited virus spread. Using pharmacological approaches, we revealed that pro-inflammatory cytokines and interferon-beta induced by TLR3 could restrict Marek's disease virus infection. This study contributes to elucidating the function and mechanism of the TLR3 pathway in host immune responses against MDV infection.
引用
收藏
页码：70847 / 70853
页数：7
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