A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery

被引：117

作者：

Epstein-Barash, Hila ^{[1
,2
]}

Orbey, Gizem ^{[3
]}

Polat, Bans E. ^{[2
]}

Ewoldt, Randy H. ^{[4
]}

Feshitan, Jameel ^{[5
]}

Langer, Robert ^{[2
]}

Borden, Mark A. ^{[5
]}

Kohane, Daniel S. ^{[1
]}

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med, Div Crit Care Med,Dept Anesthesiol,Lab Biomat & D, Boston, MA 02115 USA

[2] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[3] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

[4] MIT, Dept Mech Engn, Cambridge, MA 01239 USA

[5] Columbia Univ, Dept Chem Engn, New York, NY 10027 USA

来源：

BIOMATERIALS | 2010年 / 31卷 / 19期

关键词：

On-demand; Triggered-release; Ultrasound; Drug delivery; Hydrogels; HYALURONIC-ACID; LIPOSOMES; RELEASE; MICROBUBBLES; ADHESIONS;

D O I：

10.1016/j.biomaterials.2010.03.008

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Here we develop an injectable composite system based for repeated ultrasound-triggered on-demand drug delivery. An in situ-cross-linking hydrogel maintains model drug (dye)-containing liposomes in close proximity to gas-filled microbubbles that serve to enhance release events induced by ultrasound application. Dye release is tunable by varying the proportions of the liposomal and microbubble components, as well as the duration and intensity of the ultrasound pulses in vitro. Dye is minimal at baseline. The composite shows minimal cytotoxicity in vitro, and benign tissue reaction after subcutaneous injection in rats. Ultrasound application also triggers drug release for two weeks after injection in vivo. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5208 / 5217

页数：10

共 23 条

[1]

BARTLETT GR, 1959, J BIOL CHEM, V234, P466

[2] A Drug-Eluting Contact Lens [J].

Ciolino, Joseph B. ;

Hoare, Todd R. ;

Iwata, Naomi G. ;

Behlau, Irmgard ;

Dohlman, Claes H. ;

Langer, Robert ;

Kohane, Daniel S. .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2009, 50 (07) :3346-3352

[3] Preparation of Alendronate Liposomes for Enhanced Stability and Bioactivity: In Vitro and In Vivo Characterization [J].

Epstein, Hila ;

Gutman, Dikla ;

Cohen-Sela, Einat ;

Haber, Elran ;

Elmalak, Omar ;

Koroukhov, Nickolay ;

Danenberg, Haim D. ;

Golomb, Gershon .

AAPS JOURNAL, 2008, 10 (04) :505-515

[4] Prolonged duration local anesthesia with minimal toxicity [J].

Epstein-Barash, Hila ;

Shichor, Iris ;

Kwon, Albert H. ;

Hall, Sherwood ;

Lawlor, Michael W. ;

Langer, Robert ;

Kohane, Daniel S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (17) :7125-7130

[5] Microbubble size isolation by differential centrifugation [J].

Feshitan, Jameel A. ;

Chen, Cherry C. ;

Kwan, James J. ;

Borden, Mark A. .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2009, 329 (02) :316-324

[6] A Magnetically Triggered Composite Membrane for On-Demand Drug Delivery [J].

Hoare, Todd ;

Santamaria, Jesus ;

Goya, Gerardo F. ;

Irusta, Silvia ;

Lin, Debora ;

Lau, Samantha ;

Padera, Robert ;

Langer, Robert ;

Kohane, Daniel S. .

NANO LETTERS, 2009, 9 (10) :3651-3657

[7] Injectable in situ cross-linking hydrogels for local antifungal therapy [J].

Hudson, Sarah P. ;

Langer, Robert ;

Fink, Gerald R. ;

Kohane, Daniel S. .

BIOMATERIALS, 2010, 31 (06) :1444-1452

[8] Dextran-based in situ cross-linked injectable hydrogels to prevent peritoneal adhesions [J].

Ito, Taichi ;

Yeo, Yoon ;

Highley, Christopher B. ;

Bellas, Evangelia ;

Kohane, Daniel S. .

BIOMATERIALS, 2007, 28 (23) :3418-3426

[9] The prevention of peritoneal adhesions by in situ cross-linking hydrogels of hyaluronic acid and cellulose derivatives [J].

Ito, Taichi ;

Yeo, Yoon ;

Highley, Christopher B. ;

Bellas, Evangelia ;

Benitez, Carlos A. ;

Kohane, Daniel S. .

BIOMATERIALS, 2007, 28 (06) :975-983

[10] Prolongation of sciatic nerve blockade by in situ cross-linked hyaluronic acid [J].

Jia, XQ ;

Colombo, G ;

Padera, R ;

Langer, R ;

Kohane, DS .

BIOMATERIALS, 2004, 25 (19) :4797-4804

← 1 2 3 →